Cambridge id 6350176

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: Cambridge id 6350176
• 英文别名: 4-hydroxy-2-[(8-methoxy-4-methylquinazolin-2-yl)amino]-1H-pyrimidin-6-one
• 化学式: C₁₄H₁₃N₅O₃
• 分子量: 299.28
• InChiKey: FKYRCNWTOZWMTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  109
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] COMPOSITIONS AND METHODS OF TREATING DRUG-RESISTANT RETROVIRAL INFECTIONS<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT D'INFECTIONS RÉTROVIRALES PHARMACORÉSISTANTES
  申请人：TRANA DISCOVERY INC

  公开号：WO2012079032A2

  公开（公告）日：2012-06-14

  Methods of treating drug-resistant retroviral infections, such as those caused by drug- resistant HIV-I, HIV-II, and HIV-III, are disclosed. The methods involve administering a compound that is an inhibitor of retroviral propagation. The inhibitors inhibits the ability of any portion of the HIV genome involved in reverse transcription to bind to or associate with a host cell tRNA, or the inhibitor disrupts the RNA/RNA complex formed between the viral genome and the human tRNA primer, or the binding or association of the host cell tRNA to a retroviral genome initiates, primes, or facilitates reverse transcription of the retroviral genome in the absence of the administered compound.