This is also true for the free base 1, whereas 3 has C-5 trigonal. The di- and triacetyl derivatives of 1–3 are shown to be N,N′-di- and N,N,N′-triacetyl derivatives. Ethyl 2-cyano-3-ethoxyacrylate and 2-cyano-3-ethoxyacrylonitrile react with 1 at C-5.
NMR对
2,4-二氨基噻唑1的氢卤化物及其5-甲基和5-苯基衍
生物2和3的NMR研究表明,它们以具有C-5四面体的单一非芳族互变异构体形式存在。对于游离碱1也是这样,而3具有C-5三角形。的二-和三乙酰衍
生物1 - 3被示出为N,N'-二-和N,N,N'-三乙酰衍
生物。
2-氰基-3-乙氧基丙烯酸乙酯和2-
氰基-
3-乙氧基丙烯腈在C-5处与1反应。