3-Methyl-N-[6-(3-methyl-butyrylamino)-pyridin-2-yl]-butyramide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Methyl-N-[6-(3-methyl-butyrylamino)-pyridin-2-yl]-butyramide
• 英文别名: N,N'-2,6-pyridinediylbis(3-methylbutanamide)；3-methyl-N-[6-(3-methylbutanoylamino)pyridin-2-yl]butanamide
• 化学式: C₁₅H₂₃N₃O₂
• 分子量: 277.367
• InChiKey: WZNZWYULBRTMJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  71.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  马来酰亚胺 、 3-Methyl-N-[6-(3-methyl-butyrylamino)-pyridin-2-yl]-butyramide 以 氘代氯仿 为溶剂， 生成 3-Methyl-N-[6-(3-methyl-butyrylamino)-pyridin-2-yl]-butyramide; compound with pyrrole-2,5-dione
  参考文献：
  名称：

  Acceleration of a dipolar cycloaddition by a simple bisamide receptor

  摘要：

  A bisamide receptor has been synthesized which is capable of binding and, hence, polarizing maleimide. The hydrogen bonds formed between the receptor and maleimide alter its inherent reactivity. Full kinetic investigations, performed using H-1 NMR spectroscopy and computer-based simulation, reveal that the formation of the 1:1 complex increases the rate of the cycloaddition between maleimide and diphenyl-nitrone fivefold. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00644-4