(2E)-2-[(6-bromo-1,3-benzodioxol-5-yl)methylidene]-1-azabicyclo[2.2.2]octan-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: (2E)-2-[(6-bromo-1,3-benzodioxol-5-yl)methylidene]-1-azabicyclo[2.2.2]octan-3-one
• 化学式: C₁₅H₁₄BrNO₃
• 分子量: 336.18
• InChiKey: QUKVRKPJMOGTMO-LFYBBSHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Lactate dehydrogenase inhibitor and antiepileptic drug containing the same
  申请人：NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY

  公开号：US10350192B2

  公开（公告）日：2019-07-16

  The invention provides a lactate dehydrogenase inhibitor that makes it possible to suppress refractory epilepsy in which conventional antiepileptic drugs are ineffective, and an antiepileptic drug containing said inhibitor. The lactate dehydrogenase inhibitor of the invention contains a compound represented by formula (III); i.e., isosafrole or a compound having isosafrole as a scaffold, and the antiepileptic drug of the invention has these compounds as an active ingredient.

  本发明提供了一种乳酸脱氢酶抑制剂，可以抑制常规抗癫痫药物无效的难治性癫痫，以及一种含有上述抑制剂的抗癫痫药物。本发明的乳酸脱氢酶抑制剂含有由式（III）代表的化合物；即异黄樟素或以异黄樟素为支架的化合物，本发明的抗癫痫药物以这些化合物为有效成分。
• LACTATE DEHYDROGENASE INHIBITOR AND ANTIEPILEPTIC DRUG CONTAINING THE SAME
  申请人：NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY

  公开号：US20180015068A1

  公开（公告）日：2018-01-18

  The invention provides a lactate dehydrogenase inhibitor that makes it possible to suppress refractory epilepsy in which conventional antiepileptic drugs are ineffective, and an antiepileptic drug containing said inhibitor. The lactate dehydrogenase inhibitor of the invention contains a compound represented by formula (III); i.e., isosafrole or a compound having isosafrole as a scaffold, and the antiepileptic drug of the invention has these compounds as an active ingredient.