1-({[(1S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}oxy)pyrrolidine-2,5-dione | 1534326-80-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 1-({[(1S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}oxy)pyrrolidine-2,5-dione
• 英文别名: 2,5-Dioxopyrrolidin-1-yl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate；(2,5-dioxopyrrolidin-1-yl) (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate
• CAS: 1534326-80-1
• 化学式: C₂₀H₁₈N₂O₄
• 分子量: 350.374
• InChiKey: QPONJQKOPGKHTE-IBGZPJMESA-N

物化性质

• 沸点：
  502.8±60.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于二氯甲烷、乙酸乙酯

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N,N'-二琥珀酰亚胺基碳酸酯 、 (S)-1-苯基-1,2,3,4-四氢异喹啉 以 乙腈 为溶剂， 反应 2.0h， 以78%的产率得到1-({[(1S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}oxy)pyrrolidine-2,5-dione
  参考文献：
  名称：

  [EN] A PROCESS FOR THE PREPARATION OF SOLIFENACIN OR A SALT THEREOF
  [FR] PROCÉDÉ POUR LA PRÉPARATION DE SOLIFÉNACINE OU D'UN DE SES SELS

  摘要：

  本发明涉及一种改进的用于制备化合物Solifenacin或其式I盐的过程，更具体地说，本发明涉及一种经济可行且在工业上具有优势的过程，用于制备高纯度的Solifenacin或其式I盐。

  公开号：

  WO2014005601A1

文献信息

• Method for producing solifenacin or salts thereof
  申请人：Inakoshi Masatoshi

  公开号：US20070185329A1

  公开（公告）日：2007-08-09

  There is provided a novel method for producing solifenacin or a salt thereof which is useful as a medicine, particularly a therapeutic agent and/or a preventive agent for a urinary organ system disease such as pollakiuria or urinary incontinence. Illustratively, there are provided (1) a method for producing solifenacin in which 2-(1H-imidazolylcarbonyl)-1-phenyltetrahydroisoquinoline is used as the starting material, (2) a method for producing solifenacin succinate in which (1RS)-phenyltetrahydroisoquinoline-carboxylic acid quinuclidinyl ester is used as the starting material, (3) a method for producing solifenacin in which a lower alkyl quinuclidinyl carbonate is used as the starting material and (4) a method for producing solifenacin in which phenyltetrahydroisoquinoline-carboxylic acid secondary lower alkyl or tertiary lower alkyl ester is used as the starting material and allowed to react with an alkali metal lower alkoxide.

  提供了一种新的制备索利费南或其盐的方法，该方法可用作药物，特别是用于治疗和/或预防尿生殖器官疾病，如尿频或尿失禁的治疗剂和/或预防剂。例如，提供了以下四种方法：（1）使用2-（1H-咪唑基）-1-苯基四氢异喹啉作为起始材料制备索利费南的方法；（2）使用（1RS）-苯基四氢异喹啉-羧酸奎尼克啶酯作为起始材料制备索利费南琥珀酸盐的方法；（3）使用较低烷基奎尼库啶碳酸酯作为起始材料制备索利费南的方法；（4）使用苯基四氢异喹啉-羧酸次级较低烷基或三级较低烷基酯作为起始材料，并与碱金属较低烷氧化物反应制备索利费南的方法。
• PROCESS FOR PRODUCING SOLIFENACIN OR ITS SALT
  申请人：Astellas Pharma Inc.

  公开号：EP1757604A1

  公开（公告）日：2007-02-28

  There is provided a novel method for producing solifenacin or a salt thereof which is useful as a medicine, particularly a therapeutic agent and/or a preventive agent for a urinary organ system disease such as pollakiuria or urinary incontinence. Illustratively, there are provided (1) a method for producing solifenacin in which 2-(1H-imidazolylcarbonyl)-1-phenyltetrahydroisoquinoline is used as the starting material, (2) a method for producing solifenacin succinate in which (1RS)-phenyltetrahydroisoquinoline-carboxylic acid quinuclidinyl ester is used as the starting material, (3) a method for producing solifenacin in which a lower alkyl quinuclidinyl carbonate is used as the starting material and (4) a method for producing solifenacin in which phenyltetrahydroisoquinoline-carboxylic acid secondary lower alkyl or tertiary lower alkyl ester is used as the starting material and allowed to react with an alkali metal lower alkoxide.

  本发明提供了一种生产索利芬那新或其盐的新方法，该方法可用作药物，特别是泌尿器官系统疾病（如花粉尿症或尿失禁）的治疗剂和/或预防剂。示例性地，提供了(1)一种生产索利那新的方法，其中使用 2-(1H-咪唑羰基)-1-苯基四氢异喹啉作为起始原料；(2)一种生产索利那新琥珀酸酯的方法，其中使用(1RS)-苯基四氢异喹啉-羧酸奎宁酯作为起始原料、(4) 以苯基四氢异喹啉-羧酸仲低级烷基酯或叔低级烷基酯为起始原料，使其与碱金属低级烷氧基化合物反应，生产索利那新的方法。
• Synthesis of solifenacin monosuccinate
  申请人：Astellas Pharma Inc.

  公开号：EP2305676B1

  公开（公告）日：2012-10-17
• US7829715B2
  申请人：——

  公开号：US7829715B2

  公开（公告）日：2010-11-09