Tris(4-methylpiperidin-1-YL)-1,3,5-triazine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Tris(4-methylpiperidin-1-YL)-1,3,5-triazine
• 英文别名: 2,4,6-tris(4-methylpiperidin-1-yl)-1,3,5-triazine
• 化学式: C₂₁H₃₆N₆
• mdl: MFCD00822844
• 分子量: 372.6
• InChiKey: CDBLPNONDPRNGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• PROTECTED FLUORESCENT REAGENT COMPOUNDS
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20150050659A1

  公开（公告）日：2015-02-19

  Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.

  提供了受保护的荧光试剂化合物及其合成方法。这些化合物在各种基于荧光的分析方法中很有用，包括在高密度下对大量高度多重光学反应进行分析，例如单分子实时核酸测序反应。这些化合物包含荧光染料元素，使得这些化合物能够在理想波长下以高灵敏度被检测到，结合元素，使得这些化合物能够被特异性地识别目标生物分子，并且保护盾元素，减少荧光染料元素与结合的目标生物分子之间的不良接触，从而减少荧光染料元素对结合的目标生物分子造成的光损伤。
• MULTIMERIC PROTECTED FLUORESCENT REAGENTS
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20160237279A1

  公开（公告）日：2016-08-18

  Multimeric protected fluorescent reagents and their methods of synthesis are provided. The reagents are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The reagents contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. The reagents also contain coupling elements connect monomeric compounds into multimeric forms, thereby increasing brightness.

  提供了多聚保护荧光试剂及其合成方法。这些试剂在各种基于荧光的分析方法中很有用，包括在高密度下分析高度多重光学反应，比如单分子实时核酸测序反应。这些试剂包含荧光染料元素，允许化合物在理想波长下以高灵敏度被检测，结合元素，允许化合物被目标生物分子特异性识别，以及保护屏障元素，减少荧光染料元素与结合的目标生物分子之间的不良接触，从而减少荧光染料元素对结合的目标生物分子的光损伤。这些试剂还包含耦合元素，将单体化合物连接成多聚形式，从而增加亮度。
• CYANINE DYES
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20150072894A1

  公开（公告）日：2015-03-12

  The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.

  本发明提供了一种新型的靛绿染料，其功能化为磺酸基团和连接基团，可促进其与其他物种和取代基团的共轭，并增加水溶性和优化染料的光学性质。同时，还提供了染料的共轭物、使用染料及其共轭物的方法以及包括染料及其共轭物的试剂盒。
• Protected fluorescent reagent compounds
  申请人：Pacific Biosciences of California, Inc.

  公开号：US10800805B2

  公开（公告）日：2020-10-13

  Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.

  提供了受保护的荧光试剂化合物及其合成方法。这些化合物适用于各种基于荧光的分析方法，包括分析大量高密度的高度复用光学反应，如单分子实时核酸测序反应。这些化合物含有荧光染料元件，可在理想波长下以高灵敏度检测化合物；含有结合元件，可使化合物被目标生物大分子特异性识别；还含有保护罩元件，可减少荧光染料元件与结合的目标生物大分子之间的不良接触，从而减少荧光染料元件对结合的目标生物大分子的光损伤。
• Multimeric protected fluorescent reagents
  申请人：Pacific Biosciences of California, Inc.

  公开号：US10787573B2

  公开（公告）日：2020-09-29

  Multimeric protected fluorescent reagents and their methods of synthesis are provided. The reagents are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The reagents contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. The reagents also contain coupling elements connect monomeric compounds into multimeric forms, thereby increasing brightness.

  本文提供了多聚体保护荧光试剂及其合成方法。这些试剂适用于各种基于荧光的分析方法，包括分析大量高密度的高度复用光学反应，如单分子实时核酸测序反应。这些试剂含有荧光染料元件，可在理想波长下以高灵敏度检测化合物；结合元件，可使化合物被目标生物大分子特异性识别；保护罩元件，可减少荧光染料元件与结合的目标生物大分子之间的不良接触，从而减少荧光染料元件对结合的目标生物大分子的光损伤。试剂中还含有将单体化合物连接成多聚体形式的偶联元件，从而提高亮度。