9-(3-chloro-4-hydroxy-5-methoxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione | 382170-79-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 9-(3-chloro-4-hydroxy-5-methoxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
• 英文别名: 9-(3-Chloro-4-hydroxy-5-methoxyphenyl)-3,3,6,6-tetramethyl-2,3,4,5,6,7,8,9-octahydro-1H-xanthene-1,8-dione；9-(3-chloro-4-hydroxy-5-methoxyphenyl)-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-xanthene-1,8-dione
• CAS: 382170-79-8
• 化学式: C₂₄H₂₇ClO₅
• mdl: MFCD02209663
• 分子量: 430.928
• InChiKey: QFKNQERRCUOCAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] XANTHENEDIONE DERIVATIVES FOR THE TREATMENT OF PIGMENTATION AND SKIN AGEING DISORDERS<br/>[FR] DÉRIVÉS DE XANTHÈNEDIONE POUR LE TRAITEMENT DE TROUBLES DE PIGMENTATION ET DE VIEILLISSEMENT DE LA PEAU
  申请人：FABRE PIERRE DERMO COSMETIQUE

  公开号：WO2012004390A1

  公开（公告）日：2012-01-12

  The invention relates to compound of generic formula (I) in which: R1 and R2 represent: OH, a hydrogen atom, a C1-C6 alkyl radical a C1-C6 alkoxy radical, a halogen, or OCOR3; R3 represents: a C1-C24 alkyl radical a C12-C24 alkenyl radical comprising at least one unsaturation; R4 represents: COR5, a glucide substituted or not by one or more acetyl radical(s); R5 represents: a C10-C24 alkyl radical or a C12-C24 alkenyl radical comprising at least one unsaturation; R6 and R7 represent: - simultaneously a hydrogen atom or a methyl radical, or - when R6 represents a hydrogen atom, R7 represents a C1-C6 alkyl radical or a phenyl substituted or not by one or more C1-C3 alkoxy radical(s) or one or more halogen(s) or - R6 and R7 are bonded together and form a C3-C6 cycloalkyl, and pharmaceutically or cosmetically acceptable salts.

  该发明涉及通式(I)的化合物，其中：R1和R2代表：OH，氢原子，C1-C6烷基基团，C1-C6烷氧基团，卤素，或OCOR3；R3代表：C1-C24烷基基团，至少含有一种不饱和的C12-C24烯基基团；R4代表：COR5，一种被一个或多个乙酰基取代或未取代的糖苷；R5代表：C10-C24烷基基团或至少含有一种不饱和的C12-C24烯基基团；R6和R7代表：-同时是氢原子或甲基基团，或-当R6代表氢原子时，R7代表C1-C6烷基基团或一个被一个或多个C1-C3烷氧基或一个或多个卤素取代或未取代的苯基；或-R6和R7结合在一起形成一个C3-C6环烷基，并且是药用或化妆品中可接受的盐。
• XANTHENEDIONE DERIVATIVES FOR THE TREATMENT OF PIGMENTATION AND SKIN AGEING DISORDERS
  申请人：Poigny Stéphane

  公开号：US20130108568A1

  公开（公告）日：2013-05-02

  The invention relates to compound of generic formula (I) in which: R 1 and R 2 represent: OH, a hydrogen atom, a C 1 -C 6 alkyl radical a C 1 -C 6 alkoxy radical, a halogen, or OCOR 3 ; R 3 represents: a C 1 -C 24 alkyl radical a C 12 -C 24 alkenyl radical comprising at least one unsaturation; R 4 represents: COR 5 , a glucide substituted or not by one or more acetyl radical(s); R 5 represents: a C 10 -C 24 alkyl radical or a C 12 -C 24 alkenyl radical comprising at least one unsaturation; R 6 and R 7 represent:—simultaneously a hydrogen atom or a methyl radical, or—when R 6 represents a hydrogen atom, R 7 represents a C 1 -C 6 alkyl radical or a phenyl substituted or not by one or more C 1 -C 3 alkoxy radical(s) or one or more halogen(s) or—R 6 and R 7 are bonded together and form a C 3 -C 6 cycloalkyl, and pharmaceutically or cosmetically acceptable salts.
• US8906416B2
  申请人：——

  公开号：US8906416B2

  公开（公告）日：2014-12-09