2-[(3,5-Dimethoxyphenyl)methyl]-2-prop-2-enylpropanedioic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 2-[(3,5-Dimethoxyphenyl)methyl]-2-prop-2-enylpropanedioic acid
• 化学式: C₁₅H₁₈O₆
• 分子量: 294.3
• InChiKey: JRABSEWPBYLFOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• INHIBITORS OF BIOTIN PROTEIN LIGASE
  申请人：Adelaide Research & Innovation PTY Ltd

  公开号：EP1815006A1

  公开（公告）日：2007-08-08
• EP1815006A4
  申请人：——

  公开号：EP1815006A4

  公开（公告）日：2009-01-28
• Inhibitors Of Biotin Protein Ligase
  申请人：Polyak Steven William

  公开号：US20090118372A1

  公开（公告）日：2009-05-07

  The present invention relates to a method for identifying an inhibitor of a biotin protein ligase. The method include the steps of (a) providing a substrate, wherein the substrate may be biotinylated; (b) contacting the substrate with biotin and a biotin protein ligase in the presence of a test compound; (c) determining the extent of biotinylation of the substrate by the biotin protein ligase in the presence of the test compound; and (d) identifying the test compound as an inhibitor of the biotin protein ligase by a reduction in the biotinylation of the substrate in the presence of the test compound as compared to the extent of biotinylation of the substrate in the absence of the test compound.
• [EN] INHIBITORS OF BIOTIN PROTEIN LIGASE<br/>[FR] INHIBITEURS DE LIGASE DE PROTEINE DE BIOTINE
  申请人：ADELAIDE RES & INNOVATION PTY

  公开号：WO2006056007A1

  公开（公告）日：2006-06-01

  [EN] The present invention relates to a method for identifying an inhibitor of a biotin protein ligase. The method include the steps of (a) providing a substrate, wherein the substrate may be biotinylated; (b) contacting the substrate with biotin and a biotin protein ligase in the presence of a test compound; (c) determining the extent of biotinylation of the substrate by the biotin protein ligase in the presence of the test compound; and (d) identifying the test compound as an inhibitor of the biotin protein ligase by a reduction in the biotinylation of the substrate in the presence of the test compound as compared to the extent of biotinylation of the substrate in the absence of the test compound.
  [FR] L'invention concerne une méthode pour identifier un inhibiteur de ligase de protéine de biotine. Cette méthode comprend les étapes consistant à: (a) fournir un substrat, ce substrat pouvant être biotinylé; (b) mettre en contact le substrat avec de la biotine et avec une ligase de protéine de biotine, en présence d'un composé test; (c) déterminer l'étendue de la biotinilysation du substrat par la ligase de protéine de biotine, en présence du composé test; et (d) identifier le composé test comme inhibiteur de la ligase de protéine de biotine, par un réduction de la biotinilysation du substrat en présence du composé test, comparé à l'étendue de la biotinilysation du substrat en l'absence de ce composé test.