2-[(1,4-Dioxo-3-sulfanylnaphthalen-2-yl)amino]acetic acid | 1356827-40-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[(1,4-Dioxo-3-sulfanylnaphthalen-2-yl)amino]acetic acid
• CAS: 1356827-40-1
• 化学式: C₁₂H₉NO₄S
• 分子量: 263.274
• InChiKey: AKWKNHWQMXDWBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  84.5
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氨基-3-氯-1,4-萘醌 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 5.0h， 生成 2-[(1,4-Dioxo-3-sulfanylnaphthalen-2-yl)amino]acetic acid
  参考文献：
  名称：

  Novel 2,3-disubstituted 1,4-naphthoquinone derivatives and their metal complexes – Synthesis and in vitro cytotoxic effect against mouse fibrosarcoma L929 cells

  摘要：

  Quinones have various pharmacological properties including antibacterial, antifungal, antiviral, anti-inflammatory, antipyretic and anticancer activity. Two novel 2,3-disubstituted 1,4-naphthoquinones and their metal complexes were synthesised, characterized and tested. The cytotoxic potential of the novel 2,3-disubstituted 1,4-naphthoquinones and their metal complexes was studied against L929 murine fibroblasts cells grown in vitro. The treatment resulted in a concentration-dependent cytotoxicity as indicated by MTT assay. (C) 2011 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2011.10.036