3-(8-Pentadecenyl)-1,2-benzenediol | 2764-91-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-(8-Pentadecenyl)-1,2-benzenediol
• 英文别名: 3-[(E)-pentadec-8-enyl]benzene-1,2-diol
• CAS: 2764-91-2
• 化学式: C₂₁H₃₄O₂
• 分子量: 318.5
• InChiKey: GWOCLAPCXDOJRL-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  23
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• WGK Germany：
  3

文献信息

• COMPOSITION, COMPOSITE PREPARED FROM THE COMPOSITION, ELECTRODE USING THE COMPOSITION OR THE COMPOSITE, COMPOSITE MEMBRANE INCLUDING THE COMPOSITE, AND FUEL CELL INCLUDING THE COMPOSITE MEMBRANE
  申请人：Samsung Electronics Co., Ltd

  公开号：EP2595229B1

  公开（公告）日：2016-02-10
• USE OF AN URUSHIOL COMPOUND IN PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR INHIBITING SMAD3 PHOSPHORYLATION
  申请人：Southern Hospital, Southern Medical University

  公开号：US20150175511A1

  公开（公告）日：2015-06-25

  The invention relates to a use of an urushiol compound (code named GQ-5) in preparation of pharmaceutical compositions for inhibiting Smad3 phosphorylation. We verify that GQ-5 inhibited the interaction of Smad3 with TGF-β type I receptor (TβRI), inhibited subsequent phosphorylation of Smad3, reduced nuclear translocation of Smads complex, and suppressed the transcription of major fibrotic genes such as α-smooth muscle actin (α-SMA), collagen I and fibronectin. Therefore, GQ-5 could be a potent and selective inhibitor of TGF-β1-induced Smad3 phosphorylation, and be used to prepare pharmaceutical compositions for inhibiting Smad3 phosphorylation.
• PATCHES COMPRISING URUSHIOL, TEST PANELS COMPRISING THE SAME, AND METHODS OF USING THE SAME
  申请人：HAPTEN SCIENCES, INC.

  公开号：US20200405886A1

  公开（公告）日：2020-12-31

  Disclosed herein are urushiol-containing epicutaneous patches comprising a support material and a urushiol-containing film on a surface of the support material. A surface of the support material is coated with the urushiol-containing film. Also described herein are test panels comprising urushiol-containing epicutaneous patches of varying urushiol content. The test panels can be employed in methods to assess subject sensitivity to urushiol, to determine a dose-response relationship to varying doses of urushiol, and to assess efficacy of treatments to prevent or inhibit urushiol-induced contact dermatitis in a subject.
• US4002737A
  申请人：——

  公开号：US4002737A

  公开（公告）日：1977-01-11
• US8802315B2
  申请人：——

  公开号：US8802315B2

  公开（公告）日：2014-08-12