3-Methyl-2-oxo-2,3-dihydro-benzooxazole-6-sulfonic acid cyclohexylamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 3-Methyl-2-oxo-2,3-dihydro-benzooxazole-6-sulfonic acid cyclohexylamide
• 英文别名: N-cyclohexyl-3-methyl-2-oxo-1,3-benzoxazole-6-sulfonamide
• 化学式: C₁₄H₁₈N₂O₄S
• 分子量: 310.37
• InChiKey: MHRBGRVYNINWEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  84.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PKM2 ACTIVATORS FOR USE IN THE TREATMENT OF CANCER
  申请人：Agios Pharmaceuticals, Inc.

  公开号：EP2427441B1

  公开（公告）日：2016-12-14
• PKM2 MODULATORS FOR USE IN THE TREATMENT OF CANCER
  申请人：Salituro Francesco G.

  公开号：US20120122849A1

  公开（公告）日：2012-05-17

  Compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are pharmaceutical compositions comprising the compounds, and methods of using the compounds in the treatment of cancer.
• ACTIVATORS OF PYRUVATE KINASE M2 AND METHODS OF TREATING DISEASE
  申请人：Kung Charles

  公开号：US20140249150A1

  公开（公告）日：2014-09-04

  The invention described herein features methods, compositions, and kits that utilize activators of pyruvate kinase M2 (PKM2) for the treatment or amelioration of disorders related to PKM2 function and characterized by abnormally low levels of serine.
• US8501953B2
  申请人：——

  公开号：US8501953B2

  公开（公告）日：2013-08-06
• [EN] PMK2 MODULATORS FOR USE IN THE TREATMENT OF CANCER<br/>[FR] INHIBITEURS DE LA PKM2 DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DU CANCER
  申请人：AGIOS PHARMACEUTICALS INC

  公开号：WO2010129596A1

  公开（公告）日：2010-11-11

  Compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are pharmaceutical compositions comprising the compounds, and methods of using the compounds in the treatment of cancer.