2-(4-Bromophenyl)-4-piperidin-1-ylquinazoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(4-Bromophenyl)-4-piperidin-1-ylquinazoline
• 化学式: C₁₉H₁₈BrN₃
• 分子量: 368.3
• InChiKey: BQELZNSOCYITOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  29
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• SCREENING METHODS FOR IDENTIFYING SPECIFIC STAPHYLOCOCCUS AUREUS INHIBITORS
  申请人：Guenther Richard H.

  公开号：US20140163037A1

  公开（公告）日：2014-06-12

  Methods of inhibiting S. aureus propagation, and screening for compounds that inhibit S. aureus propagation, are described. A method of inhibiting S. aureus propagation comprises either inhibiting or stabilizing ribosomal binding of a specific S. aureus tRNA in the S. aureus by an amount sufficient to inhibit S. aureus protein expression. A method of screening for compounds useful for inhibiting S. aureus propagation comprises contacting a specific S. aureus tRNA to a ribosome that binds that tRNA in the presence of the test compound and an mRNA that codes for methionine and arginine (i.e., includes the sequence AUGAGA), and then determining whether the compound inhibits the binding of that tRNA.
• US8153642B2
  申请人：——

  公开号：US8153642B2

  公开（公告）日：2012-04-10
• US8343980B2
  申请人：——

  公开号：US8343980B2

  公开（公告）日：2013-01-01