5-(3-Bromo-4-hydroxy-5-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-(3-Bromo-4-hydroxy-5-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
• 英文别名: (5Z)-5-[(3-bromo-4-hydroxy-5-methoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• 化学式: C₁₁H₈BrNO₃S₂
• 分子量: 346.2
• InChiKey: SHLGFNMWSDCHHW-YWEYNIOJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] SMALL MOLECULE CD38 INHIBITORS AND METHODS OF USING SAME<br/>[FR] INHIBITEURS DE CD38 À PETITES MOLÉCULES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：HARVARD COLLEGE

  公开号：WO2013002879A1

  公开（公告）日：2013-01-03

  The invention provides methods and compositions for inhibiting CD 38 activity, and methods of treating or preventing various disorders associated with CD38 activity.

  这项发明提供了抑制CD38活性的方法和组合物，以及治疗或预防与CD38活性相关的各种疾病的方法。
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  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0343643A2

  公开（公告）日：1989-11-29

  The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula having activity useful for treating allergies and inflammation.

  本发明涉及所选的新型化合物，以及已知和所选的新型化合物的药物组合物和使用方法，这两种化合物的化学式均为 具有治疗过敏症和炎症的活性。
• SMALL MOLECULES AS ANTIAGING AGENTS
  申请人：President and Fellows of Harvard College

  公开号：EP3345901A2

  公开（公告）日：2018-07-11

  The application provides an agent selected from nicotinamide riboside, tryptophan, quinolinic acid, nicotinamide, nicotinamide mononucleotide, and nicotinic acid for use in: i) retarding, treating, or preventing an age-related disease in a subject; or ii) retarding aging in a subject; or iii) imparting the benefits of diet or exercise to a subject.

  本申请提供了一种选自烟酰胺核糖甙、色氨酸、喹啉酸、烟酰胺、烟酰胺单核苷酸和烟酸的制剂，用于 i) 延缓、治疗或预防受试者与年龄有关的疾病；或 延缓受试者的衰老；或 iii) 向受试者传授饮食或运动的益处。
• IN VIVO METHODS FOR ENHANCING BIOENERGETIC STATUS IN FEMALE GERM CELLS
  申请人：The General Hospital Corporation

  公开号：EP3495470A1

  公开（公告）日：2019-06-12

  Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.

  描述了包含生物能剂的组合物和方法，用于恢复老化卵母细胞的质量，增强卵母干细胞或改善其衍生物（如细胞质或分离的线粒体），以用于生育力增强程序。
• Small Molecule CD38 Inhibitors and Methods of Using Same
  申请人：Sinclair David A.

  公开号：US20140221319A1

  公开（公告）日：2014-08-07

  The invention provides methods and compositions for inhibiting CD 38 activity, and methods of treating or preventing various disorders associated with CD38 activity.