1-benzyl-5-methyl-1H-indazole | 55661-69-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 1-benzyl-5-methyl-1H-indazole
• 英文别名: 1-Benzyl-5-methyl-1H-indazol；1-Benzyl-5-methylindazole
• CAS: 55661-69-3
• 化学式: C₁₅H₁₄N₂
• 分子量: 222.29
• InChiKey: ONWCMPATYVRELB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5-甲基-1H-吲唑 、 氯化苄 生成 1-benzyl-5-methyl-1H-indazole 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  v. Auwers; Lohr, Journal fur praktische Chemie (Leipzig 1954), 1924, vol. <2> 108, p. 314

  摘要：

  DOI：

文献信息

• INDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T))
  申请人：GALDERMA RESEARCH & DEVELOPMENT

  公开号：US20170342062A1

  公开（公告）日：2017-11-30

  Indazole sulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of retinoid-related orphan receptor gamma RORγt are described. Pharmaceutical compositions including such compounds, as well as the use thereof for the topical and/or oral treatment of RORγt receptor-mediated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis are also described.

  本发明涉及式(I)的吲唑磺胺衍生物，其药学上可接受的加盐物，其水合物和/或溶剂合物，以及将其用作视黄醇相关孤儿受体伽玛RORγt的逆向激动剂的用途。还描述了包括这些化合物的药物组合物，以及将其用于治疗RORγt受体介导的炎症性疾病，特别是痤疮、银屑病和/或特应性皮炎的局部和/或口服治疗。
• AROMATIC COMPOUND PRODUCTION METHOD
  申请人：FUJIFILM Corporation

  公开号：US20180215716A1

  公开（公告）日：2018-08-02

  Provided is a method for producing an aromatic compound, which can produce a particular aromatic compound at high yield and can be industrially utilized. According to the invention, there is provided a method for producing an aromatic compound, including an aromatization reaction which includes reacting an oxime compound represented by Formula (1) with an acylating agent in the presence of a hydroquinone compound and a palladium compound, and thus obtaining an aromatic compound.

  提供了一种生产芳香化合物的方法，该方法可以高产地生产特定的芳香化合物，并且可以在工业上得到利用。根据本发明，提供了一种生产芳香化合物的方法，包括芳香化反应，其中包括在氢醌化合物和钯化合物的存在下，将由式（1）表示的肟化合物与酰化试剂反应，从而得到芳香化合物。
• NOVEL AMINE DERIVATIVE OR SALT THEREOF
  申请人：Toyama Chemical Co., Ltd.

  公开号：EP2915804A1

  公开（公告）日：2015-09-09

  A novel amine derivative expressed by general formula (1) (in the formula: G1, G2, and G3 are the same or different and represent CH or a nitrogen atom; R1 represents a chlorine atom, an optionally-substituted C3-8 cycloalkyl group, or the like; R2 represents -COOR5 (in the formula, R5 represents a hydrogen atom or a carboxyl protective group), or the like; R3 represents a hydrogen atom, or the like; and R4 represents an optionally-substituted condensed bicyclic hydrocarbon group, an optionally-substituted bicyclic heterocyclic group, or the like), or a salt thereof is useful in procedures such as the treatment or prevention of conditions related to excessive keratinocyte proliferation.

  通式(1)表示的新型胺衍生物 (式中G1、G2 和 G3 相同或不同，代表 CH 或氮原子；R1 代表氯原子、任选取代的 C3-8 环烷基或类似物；R2 代表 -COOR5（式中，R5 代表氢原子或羧基保护基）或类似物；R3 代表氢原子或类似物；R4代表任选取代的缩合双环烃基、任选取代的双环杂环基团或类似基团）或其盐可用于治疗或预防与角质细胞过度增殖有关的疾病。
• CYANOPYRROLIDINES AS DUB MODULATORS
  申请人：Mission Therapeutics Limited

  公开号：EP3828179A1

  公开（公告）日：2021-06-02

  The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase LI (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

  本发明涉及新型化合物和制造去泛素化酶（DUB）抑制剂的方法。特别是，本发明涉及泛素 C 端水解酶 LI（UCHL1）的抑制。本发明进一步涉及 DUB 抑制剂在治疗癌症和其他适应症中的用途。本发明的化合物包括具有式 (I) 的化合物 或其药学上可接受的盐，其中 R1 至 R8 如本文所定义。
• Compounds
  申请人：MISSION THERAPEUTICS LTD

  公开号：US10392380B2

  公开（公告）日：2019-08-27

  The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

  本发明涉及新型化合物和制造去泛素化酶（DUB）抑制剂的方法。特别是，本发明涉及泛素 C 端水解酶 L1（UCHL1）的抑制。本发明进一步涉及 DUB 抑制剂在治疗癌症和其他适应症中的用途。本发明的化合物包括具有式(I)的化合物或其药学上可接受的盐，其中R1至R8如本文所定义。