3-[2-(Diethylamino)ethyl]-1-methylquinazoline-2,4-dione | 1242134-45-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-[2-(Diethylamino)ethyl]-1-methylquinazoline-2,4-dione
• CAS: 1242134-45-7
• 化学式: C₁₅H₂₁N₃O₂
• 分子量: 275.351
• InChiKey: WNQRAGMSSWNAIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  43.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-[2-(Diethylamino)ethyl]-1-methylquinazoline-2,4-dione 在 盐酸 作用下， 以 异丙醇 为溶剂， 生成 3-(2-diethylaminoethyl)-1-methyl-1H-quinazoline-2,4-dione hydrochloride
  参考文献：
  名称：

  4-Hydroxy-2-quinolones 173*. 1-R-3-(2-diethylamino- ethyl)-1H-quinazoline- 2,4-dione hydrochlorides as potential local anesthetic agents

  摘要：

  Different variants of the preparation and procedures in the synthesis of a series of 1-R-3-(2-dialkylaminoethyl)-1H-quinazoline-2,4-dione hydrochlorides having a structural similarity to the 4-hydroxy-2-quinolinone anesthetic chinoxicaine are discussed. A comparative analysis of the biological properties of the synthesized compounds and the known local anesthetics chinoxicaine and lidocaine is reported.

  DOI：

  10.1007/s10593-010-0475-4
• 作为产物：
  描述：

  N-[2-(diethylamino)ethyl]-2-(methylamino)benzamide 、 氯甲酸甲酯 反应 10.0h， 生成 3-[2-(Diethylamino)ethyl]-1-methylquinazoline-2,4-dione
  参考文献：
  名称：

  4-Hydroxy-2-quinolones 173*. 1-R-3-(2-diethylamino- ethyl)-1H-quinazoline- 2,4-dione hydrochlorides as potential local anesthetic agents

  摘要：

  Different variants of the preparation and procedures in the synthesis of a series of 1-R-3-(2-dialkylaminoethyl)-1H-quinazoline-2,4-dione hydrochlorides having a structural similarity to the 4-hydroxy-2-quinolinone anesthetic chinoxicaine are discussed. A comparative analysis of the biological properties of the synthesized compounds and the known local anesthetics chinoxicaine and lidocaine is reported.

  DOI：

  10.1007/s10593-010-0475-4