(R)-N,N-diethylisobutylsulfinamide | 1198616-47-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 亚磺酸及其衍生物
• 英文名称: (R)-N,N-diethylisobutylsulfinamide
• 英文别名: (R)-N,N-diethyl-2-methylpropane-1-sulfinamide
• CAS: 1198616-47-5
• 化学式: C₈H₁₉NOS
• 分子量: 177.311
• InChiKey: FBBBQMMWNAKLKH-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  39.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  diethylsulfinamic acid (1R,2S)-1-phenyl-2-[(toluenesulfonyl)-amino]propyl ester 、 Isobutylmagnesium chloride 在 水 、 碳酸氢钠 作用下， 以 乙醚 为溶剂， 以90%的产率得到(R)-N,N-diethylisobutylsulfinamide
  参考文献：
  名称：

  The sulfinyl moiety in Lewis base-promoted allylations

  摘要：

  By employing Senanayake's oxathiazolidine-2-oxide reagent, a collection of sulfinamides was prepared and provided the first examples of sulfinamides promoting the allylation of benzaldehyde and N-benzoylhydrazones with allyltrichlorosilane. The optimum sulfinamide-derived Lewis base promoter displays comparable activity to the best sulfinyl-based Lewis bases reported. The use of bis-sulfoxides is also discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.09.042
• 作为试剂：
  描述：

  丙烯基三氯硅烷 、 N-苯甲酰基-N'-苄亚基肼 在 (R)-N,N-diethylisobutylsulfinamide 、 N,N-二异丙基乙胺 、 水 、 碳酸氢钠 作用下， 以 二氯甲烷 为溶剂， 生成 benzoic acid N'-(1-phenylbut-3-enyl)hydrazide 、 benzoic acid N'-(1-phenylbut-3-enyl)hydrazide
  参考文献：
  名称：

  The sulfinyl moiety in Lewis base-promoted allylations

  摘要：

  By employing Senanayake's oxathiazolidine-2-oxide reagent, a collection of sulfinamides was prepared and provided the first examples of sulfinamides promoting the allylation of benzaldehyde and N-benzoylhydrazones with allyltrichlorosilane. The optimum sulfinamide-derived Lewis base promoter displays comparable activity to the best sulfinyl-based Lewis bases reported. The use of bis-sulfoxides is also discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.09.042

文献信息

• The sulfinyl moiety in Lewis base-promoted allylations
  作者：J. Robin Fulton、Lamin M. Kamara、Simon C. Morton、Gareth J. Rowlands

  DOI：10.1016/j.tet.2009.09.042

  日期：2009.11

  By employing Senanayake's oxathiazolidine-2-oxide reagent, a collection of sulfinamides was prepared and provided the first examples of sulfinamides promoting the allylation of benzaldehyde and N-benzoylhydrazones with allyltrichlorosilane. The optimum sulfinamide-derived Lewis base promoter displays comparable activity to the best sulfinyl-based Lewis bases reported. The use of bis-sulfoxides is also discussed. (C) 2009 Elsevier Ltd. All rights reserved.