7-chloro-N-(2-pyridinylmethyl)-4-quinazolinamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-chloro-N-(2-pyridinylmethyl)-4-quinazolinamine
• 英文别名: 7-chloro-N-(pyridin-2-ylmethyl)quinazolin-4-amine
• 化学式: C₁₄H₁₁ClN₄
• 分子量: 270.72
• InChiKey: ZBSJOWIROBLROO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Substituted quinoline and quinazoline inhibitors of quinone reductase 2
  申请人：Ware W. Roy

  公开号：US20060074105A1

  公开（公告）日：2006-04-06

  The present invention provides composition and methods of inhibiting quinone reductase 2 (QR2). The methods are useful in the treatment of malaria and autoimmune diseases. The compositions of the invention comprise quinoline and quinazoline derivatives. The invention also provides methods for inhibiting the activity of QR2 by contacting the enzyme with one or more compositions of the invention.
• [EN] SUBSTITUTED QUINOLINE AND QUINAZOLINE INHIBITORS OF QUINONE REDUCTASE 2<br/>[FR] INHIBITEURS QUINOLINE ET QUINAZOLINE A SUBSTITUTION INHIBANT LA QUINONE REDUCTASE 2
  申请人：SERENEX INC

  公开号：WO2006034235A2

  公开（公告）日：2006-03-30

  The present invention provides composition and methods of inhibiting quinone reductase 2 (QR2). The methods are useful in the treatment of malaria and autoimmune diseases. The compositions of the invention comprise quinoline and quinazoline derivatives. The invention also provides methods for inhibiting the activity of QR2 by contacting the enzyme with one or more compositions of the invention.