N,N'-(1,3-dioxo-2-(2-(pyrrolidin-1-yl)ethyl)-2,3-dihydro-1H-benzo[de]isoquinoline-5,8-diyl)bis(3-(pyrrolidin-1-yl)propanamide) | 1271104-26-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N,N'-(1,3-dioxo-2-(2-(pyrrolidin-1-yl)ethyl)-2,3-dihydro-1H-benzo[de]isoquinoline-5,8-diyl)bis(3-(pyrrolidin-1-yl)propanamide)
• 英文别名: N-[1,3-dioxo-2-(2-pyrrolidin-1-ylethyl)-8-(3-pyrrolidin-1-ylpropanoylamino)benzo[de]isoquinolin-5-yl]-3-pyrrolidin-1-ylpropanamide
• CAS: 1271104-26-7
• 化学式: C₃₂H₄₂N₆O₄
• 分子量: 574.723
• InChiKey: JMCXXROBXYGHOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  42
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3,6-diamino-1,8-naphthalic anhydride 在 sodium iodide 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 8.0h， 生成 N,N'-(1,3-dioxo-2-(2-(pyrrolidin-1-yl)ethyl)-2,3-dihydro-1H-benzo[de]isoquinoline-5,8-diyl)bis(3-(pyrrolidin-1-yl)propanamide)
  参考文献：
  名称：

  Design, synthesis, biophysical and biological studies of trisubstituted naphthalimides as G-quadruplex ligands

  摘要：

  A series of trisubstituted naphthalimides have been synthesized and evaluated as telomeric G-quadruplex ligands by biophysical methods. Affinity for telomeric G-quadruplex AGGG(TTAGGG)(3) binding was first screened by fluorescence titrations. Subsequently, the interaction of the telomeric G-quadruplex with compounds showing the best affinity has been studied by isothermal titration calorimetry and UV-melting experiments. The two best compounds of the series tightly bind the telomeric quadruplex with a 2:1 drug/DNA stoichiometry. These derivatives have been further evaluated for their ability to inhibit telomerase by a TRAP assay and their pharmacological properties by treating melanoma (M14) and human lung cancer (A549) cell lines with increasing drug concentrations. A dose-dependent inhibition of cell proliferation was observed for all cellular lines during short-term treatment. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.08.062

文献信息

• Design, synthesis, biophysical and biological studies of trisubstituted naphthalimides as G-quadruplex ligands
  作者：Antonella Peduto、Bruno Pagano、Carmen Petronzi、Antonio Massa、Veronica Esposito、Antonella Virgilio、Francesco Paduano、Francesco Trapasso、Filomena Fiorito、Salvatore Florio、Concetta Giancola、Aldo Galeone、Rosanna Filosa

  DOI：10.1016/j.bmc.2011.08.062

  日期：2011.11

  A series of trisubstituted naphthalimides have been synthesized and evaluated as telomeric G-quadruplex ligands by biophysical methods. Affinity for telomeric G-quadruplex AGGG(TTAGGG)(3) binding was first screened by fluorescence titrations. Subsequently, the interaction of the telomeric G-quadruplex with compounds showing the best affinity has been studied by isothermal titration calorimetry and UV-melting experiments. The two best compounds of the series tightly bind the telomeric quadruplex with a 2:1 drug/DNA stoichiometry. These derivatives have been further evaluated for their ability to inhibit telomerase by a TRAP assay and their pharmacological properties by treating melanoma (M14) and human lung cancer (A549) cell lines with increasing drug concentrations. A dose-dependent inhibition of cell proliferation was observed for all cellular lines during short-term treatment. (C) 2011 Elsevier Ltd. All rights reserved.