N-(2,6-dimethylphenyl)-1,3-dimethyl-2-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(2,6-dimethylphenyl)-1,3-dimethyl-2-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
• 英文别名: N-(2,6-dimethylphenyl)-1,3-dimethyl-2-oxo-4H-quinazoline-6-sulfonamide
• 化学式: C₁₈H₂₁N₃O₃S
• mdl: MFCD05258098
• 分子量: 359.4
• InChiKey: HIBQXWKGYXHFGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  78.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Bicyclic PKM2 activators
  申请人：Agios Pharmaceuticals, Inc.

  公开号：US10087169B2

  公开（公告）日：2018-10-02

  Compounds and compositions comprising compounds that activate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that activate PKM2 in the treatment of cancer.

  本文描述了包含激活丙酮酸激酶 M2（PKM2）的化合物和组合物。本文还描述了使用激活 PKM2 的化合物治疗癌症的方法。
• BICYCLIC PKM2 ACTIVATORS
  申请人：Agios Pharmaceuticals, Inc.

  公开号：EP2655350B1

  公开（公告）日：2016-03-09
• PYRUVATE KINASE ACTIVATORS FOR USE FOR INCREASING LIFETIME OF THE RED BLOOD CELLS AND TREATING ANEMIA
  申请人：Su Shin-San M.

  公开号：US20140179694A1

  公开（公告）日：2014-06-26

  Described herein are methods for using compounds that activate pyruvate kinase.
• THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE
  申请人：AGIOS PHARMACEUTICALS, INC

  公开号：US20160280697A1

  公开（公告）日：2016-09-29

  Compounds and compositions comprising compounds that activate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that activate PKM2 in the treatment of cancer.
• Bicyclic PKM2 Activators
  申请人：Agios Pharmaceuticals, Inc.

  公开号：US20170369481A1

  公开（公告）日：2017-12-28

  Compounds and compositions comprising compounds that activate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that activate PKM2 in the treatment of cancer.