6-Fluoro-2-(4-methylphenyl)-1,2-benzothiazol-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 6-Fluoro-2-(4-methylphenyl)-1,2-benzothiazol-3-one
• 化学式: C₁₄H₁₀FNOS
• 分子量: 259.3
• InChiKey: XQPPJOAKKIVUQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• MIF MODULATORS
  申请人：Jorgensen William L.

  公开号：US20120040974A1

  公开（公告）日：2012-02-16

  The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low levels of MIF expression.

  该发明提供了新型杂环化合物、制药组合物和治疗方法，可调节MIF表达水平并治疗与高或低MIF表达水平有关的疾病。
• BENZOISOTHIAZOLONES AS INHIBITORS OF PHOSPHOMANNOSE ISOMERASE
  申请人：Cosford Nicholas D. P.

  公开号：US20110257233A1

  公开（公告）日：2011-10-20

  The disclosure provides new compounds and compositions thereof, and methods for treating or ameliorating a disorder relating to CDG-Ia. In particular, the disclosure provides benzoisothiazolone inhibitors of PMI, which have been synthesized and their ability to drive glycosylation has been demonstrated. The disclosure provides two synthetic routes for these compounds, including a new copper-catalyzed N-arylation reaction amenable to parallel derivitization. The disclosed compounds represent potent inhibitors of PMI, and their dose-dependent efficacy in cell-based models of glycosylation have been demonstrated. In addition, the disclosed compounds are selective over PMM and therefore, are useful in treating or ameliorating a disorder relating to CDG-Ia.
• US9540322B2
  申请人：——

  公开号：US9540322B2

  公开（公告）日：2017-01-10
• US9643922B2
  申请人：——

  公开号：US9643922B2

  公开（公告）日：2017-05-09