2-methyl-N-[(1S)-1-phenylethyl]propan-1-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-methyl-N-[(1S)-1-phenylethyl]propan-1-amine
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: GSYBPFPVGKYUTI-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (1E)-N-异丁基-1-苯基乙烷亚胺 在 三氯硅烷 、 C₁₆H₂₄F₂N₂O₂S 作用下， 以 甲苯 为溶剂， 反应 48.0h， 以85%的产率得到2-methyl-N-[(1S)-1-phenylethyl]propan-1-amine
  参考文献：
  名称：

  l-缬氨酸衍生的手性N-亚磺酰胺可作为有效的有机催化剂，用于N-烷基和N-芳基保护的酮亚胺的不对称氢化硅烷化†

  摘要：

  已经开发出L-缬氨酸衍生的N-亚磺酰胺作为有效的对映选择性路易斯碱性有机催化剂，用于用三氯硅烷不对称还原N-芳基和N-烷基酮亚胺。催化剂3c在N-烷基酮亚胺的还原中提供高达99％的收率和96％ee，在N-芳基酮亚胺的还原中提供高达98％的收率和98％ee 。

  DOI：

  10.1039/c4ob01257g

文献信息

• COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20210147383A1

  公开（公告）日：2021-05-20

  Disclosed are compounds of Formula (I): or a salt thereof, wherein: Z is CR 6 R 6 or C═O; Ring A is: and R 1 , R 2 , R 3 , R 4 , R 5 , m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

  公开的化合物为Formula (I)的化合物或其盐，其中：Z为CR6R6或C═O；环A为：而R1、R2、R3、R4、R5、m和n在此处有定义。还公开了使用这些化合物抑制Helios蛋白的方法，以及包含这些化合物的药物组合物。这些化合物在治疗病毒感染和增生性疾病（如癌症）方面非常有用。
• NOVEL BORATE DERIVATIVES AND THEIR APPLICATIONS
  申请人：HEISE Glenn L.

  公开号：US20120289733A1

  公开（公告）日：2012-11-15

  Borates, compositions comprising chiral (cyclic and acyclic) and achiral (cyclic and acyclic) borates; chiral (cyclic and acyclic) and achiral (cyclic and acyclic) biborates; and methods for their synthesis. Additionally, a significantly improved synthetic protocol for the synthesis of wide range of boronates starting from borates or biborates and Grignard or organolithium reagents that can be used for kilo lab and commercial scale production.

  硼酸盐，包括手性（环状和非环状）和非手性（环状和非环状）硼酸盐的组合物；手性（环状和非环状）和非手性（环状和非环状）双硼酸盐；以及它们的合成方法。此外，还有一种显著改进的合成方案，用于合成从硼酸盐或双硼酸盐以及格氏试剂或有机锂试剂出发的广泛范围的硼酸酯，可用于千克级实验室和商业规模生产。
• N-(2-phenylethyl)sulfamide derivatives as integrin alpha4 antagonists
  申请人：Jimenez Mayorga Miguel Juan

  公开号：US20070179183A1

  公开（公告）日：2007-08-02

  Compounds of the following formula and salts thereof are described as integrin α4-antagonists, wherein the various symbols are as defined in the specification.

  以下化合物及其盐被描述为整合素α4拮抗剂，其中各种符号如规范中定义。
• S-SUBSTITUTED N-1- (HETERO)ARYL ALKYL-N - (HETERO)ARYL ALKYLYSOTHIOCARBAMIDES, METHOD FOR THE PRODUCTION THEREOF, PHYSIOLOGICALLY ACTIVE S-SUBSTITUTED N-1- (HETERO )ARYL ALKYL-N - (HETERO)ARYL ALKYLYSOTHIOCARBAMIDES,A PHARMACEUTICAL COMPOUND AND CURING METHOD
  申请人：Institut Fiziologicheski Aktivnykh Veschestv Rossiyskov Akademii Nauk

  公开号：EP1577294A1

  公开（公告）日：2005-09-21

  The invention relates to s-substituted N-1-[(hetero)aryl]alkyl-N-1-[(hetero)aryl]alkylysothio-carbamides and the physiologically active salts and bases thereof, embodied in the form of racemic mixtures (or stereoisomer mixture) or individual optical isomers. The specific physiological activity of said compounds makes it possible to use them in the form of molecular tools. Said invention also relates to Pharmaceutical compositions, containing said compounds and to a method for preventing and curing various diseases including neurodegenerative diseases as, for example Alzheimer's disease (AD). The pharmacological effect of said compounds is based on the combined cognitive-stimulating and neuroprotective action thereof, which is produced by acting on chemo-controlled calcium channels of neurone membranes, in particular the neurones regulated by glutamate receptors of the central neural system (CNS).

  本发明涉及 s-取代的 N-1-[(杂)芳基]烷基-N-1-[(杂)芳基]烷基硫代氨基甲酸酯及其具有生理活性的盐和碱，以外消旋混合物（或立体异构体混合物）或单个光学异构体的形式体现。上述化合物的特殊生理活性使其有可能以分子工具的形式使用。本发明还涉及含有上述化合物的药物组合物，以及预防和治疗各种疾病（包括神经退行性疾病，如阿尔茨海默病（AD））的方法。所述化合物的药理作用基于其刺激认知和保护神经的综合作用，这种作用是通过作用于神经元膜的化学控制钙通道产生的，特别是受中枢神经系统（CNS）谷氨酸受体调节的神经元。
• N-(2-PHENYLETHYL)SULFAMIDE DERIVATIVES AS INTEGRIN ALPHA4 ANTAGONISTS
  申请人：Laboratorios Almirall, S.A.

  公开号：EP1622867B1

  公开（公告）日：2007-09-19