1-[(Z)-2-fluoro-2-[4-(methoxymethoxy)phenyl]ethenyl]-3,5-dimethoxybenzene | 402490-66-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-[(Z)-2-fluoro-2-[4-(methoxymethoxy)phenyl]ethenyl]-3,5-dimethoxybenzene
• CAS: 402490-66-8
• 化学式: C₁₈H₁₉FO₄
• 分子量: 318.345
• InChiKey: GHUYBBMLKYCMJS-ZDLGFXPLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-[(Z)-2-fluoro-2-[4-(methoxymethoxy)phenyl]ethenyl]-3,5-dimethoxybenzene 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 36.0h， 以76%的产率得到fluoropterostilbene
  参考文献：
  名称：

  Fluorinated resveratrol and pterostilbene

  摘要：

  A general method for the synthesis of polyhydroxylated stilbene monofluorinated on the central double bond based on the Suzuki reaction between a bromofluoroolefin and a phenylboronic acid is described. Synthesis Of fluorinated analogues of resveratrol and pterostilbene was achieved using this strategy. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01800-7
• 作为产物：
  描述：

  3,5-二甲氧基苯甲醛 在 bis-triphenylphosphine-palladium(II) chloride 锌铜偶 、 四丁基氟化铵 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 9.0h， 生成 1-[(Z)-2-fluoro-2-[4-(methoxymethoxy)phenyl]ethenyl]-3,5-dimethoxybenzene
  参考文献：
  名称：

  Fluorinated resveratrol and pterostilbene

  摘要：

  A general method for the synthesis of polyhydroxylated stilbene monofluorinated on the central double bond based on the Suzuki reaction between a bromofluoroolefin and a phenylboronic acid is described. Synthesis Of fluorinated analogues of resveratrol and pterostilbene was achieved using this strategy. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01800-7

文献信息

• Fluorinated resveratrol and pterostilbene
  作者：Said Eddarir、Zouanate Abdelhadi、Christian Rolando

  DOI：10.1016/s0040-4039(01)01800-7

  日期：2001.12

  A general method for the synthesis of polyhydroxylated stilbene monofluorinated on the central double bond based on the Suzuki reaction between a bromofluoroolefin and a phenylboronic acid is described. Synthesis Of fluorinated analogues of resveratrol and pterostilbene was achieved using this strategy. (C) 2001 Elsevier Science Ltd. All rights reserved.