(E)-N-methyl-N-(3-phenyl-2-propenyl)-2H-1-benzopyran-4-methanamine | 83554-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (E)-N-methyl-N-(3-phenyl-2-propenyl)-2H-1-benzopyran-4-methanamine
• 英文别名: Trans-N-(2H-1-benzopyran-4-yl-methyl)-N-methyl-cinnamylamine；(E)-N-(2H-chromen-4-ylmethyl)-N-methyl-3-phenylprop-2-en-1-amine
• CAS: 83554-66-9
• 化学式: C₂₀H₂₁NO
• 分子量: 291.393
• InChiKey: YAHOBIQNQUONNK-JXMROGBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-甲基肉桂基胺 、 4-chloromethyl-Δ³-chromene 在 sodium carbonate 作用下， 以 N-甲基乙酰胺 、 乙酸乙酯 为溶剂， 生成 (E)-N-methyl-N-(3-phenyl-2-propenyl)-2H-1-benzopyran-4-methanamine
  参考文献：
  名称：

  Benzopyrane and benzothiopyrane derivatives useful as anti-mycotic agents

  摘要：

  苯并吡喃和苯并噻吩衍生物具有药用特性，特别是抗真菌活性。

  公开号：

  US04382951A1

文献信息

• Benzopyrane and benzothiopyrane derivatives useful as anti-mycotic agents
  申请人：Sandoz Ltd.

  公开号：US04382951A1

  公开（公告）日：1983-05-10

  Benzopyrane and benzothiopyrane derivatives which possess pharmaceutical in particular anti-mycotic activity.

  苯并吡喃和苯并噻吩衍生物具有药用特性，特别是抗真菌活性。
• GRASSBERGER, M.;PETRANYI, G.
  作者：GRASSBERGER, M.、PETRANYI, G.

  DOI：——

  日期：——
• US4382951A
  申请人：——

  公开号：US4382951A

  公开（公告）日：1983-05-10
• Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics
  作者：Anton Stuetz、Apostolos Georgopoulos、Waltraud Granitzer、Gabor Petranyi、Daniel Berney

  DOI：10.1021/jm00151a019

  日期：1986.1

  Naftifine (1) is the first representative of the new antifungal allylamine derivatives. Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals. A tertiary allylamine function seems to be a prerequisite for activity against fungi. By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations. Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.