[(8R,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] hexanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: [(8R,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] hexanoate
• 化学式: C₂₇H₄₀O₄
• 分子量: 428.6
• InChiKey: DOMWKUIIPQCAJU-FQKQELJYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Highly concentrated pharmaceutical formulations of steroids and processes for their preparation
  申请人：AKZO N.V.

  公开号：EP0001851A1

  公开（公告）日：1979-05-16

  The invention reistse to highly concantrated liquid pharmacautical formulations of stsroids of the occtrane, and the omtrane, androstane and (19-nor) prognane series comprising tocol or a derivative thereof that is fluid se normal tomperature, or mixtures thereof, in an smount of at least 10% by weight of the formulation. and optionaly one or more of te usual suid cariers. such as vegetable oil, benzyl benzosts and/or benzyl alcohol.

  本发明涉及卵巢烷、卵烷、雄烷和(19-去甲)炔丙烷系列类固醇的高度浓缩液体药用制剂，包括在常温下具有流动性的妥尔或其衍生物，或它们的混合物，其含量至少为制剂重量的10%，还可选用一种或多种常用的添加剂，如植物油、苄基苯甲醇和/或苄醇。
• Screening and treatment methods for prevention of preterm delivery
  申请人：ADEZA BIOMEDICAL CORPORATION

  公开号：EP1936376A2

  公开（公告）日：2008-06-25

  Provided herein are methods, combinations, and kits for screening and treating a subject. In practicing the methods a sample, such as urine, blood, plasma, saliva, cervical fluid, vaginal fluid or a tissue sample, is obtained from a subject; if the level of a marker, such as a foetal restricted antigen or estriol, is indicative of a risk of imminent or preterm delivery, a progestational agent is administered to the subject. BY virtue of administration of the agent delivery can be delayed.

  本文提供了用于筛查和治疗受试者的方法、组合和试剂盒。在实施这些方法时，要从受试者身上获取尿液、血液、血浆、唾液、宫颈液、阴道液或组织样本等样本；如果胎儿限制性抗原或雌三醇等标记物的水平表明存在即将分娩或早产的风险，则要向受试者施用孕激素。通过使用这种药剂，可以推迟分娩。
• Dosage regimen for the treatment of a traumatic brain injury with progesterone
  申请人：EMORY UNIVERSITY

  公开号：EP2030622A1

  公开（公告）日：2009-03-04

  The present invention provides a method of treating traumatic brain injury. More particularly, the invention relates to the treatment of traumatic brain injury in a human subject, said treatment comprising administering to said human subject a therapeutically effective amount of progesterone by means of intravenous infusion to achieve a final progesterone serum level of about 100 ng/ml to about 1000 ng/ml

  本发明提供了一种治疗创伤性脑损伤的方法。更具体地说，本发明涉及治疗人类受试者的创伤性脑损伤，所述治疗包括通过静脉输注给所述人类受试者注射治疗有效量的孕酮，以达到约 100 纳克/毫升至约 1000 纳克/毫升的最终孕酮血清水平。
• Methods for the treatment of a traumatic central nervous system injury
  申请人：Emory University

  公开号：EP2494976A1

  公开（公告）日：2012-09-05

  A method of treating a human subject with a central nervous system injury is provided. Also provided is a method for the reduction or elimination of neuronal cell death, edema or ischemia in a human following a central nervous system injury. Furthermore a method is provided for arresting and/or reversing progression of neurodegeneration in a human following a central nervous system injury. The aforementioned methods comprise a therapy comprising a dosing regime of progesterone or synthetic progestin.

  提供了一种治疗中枢神经系统损伤患者的方法。还提供了一种减少或消除中枢神经系统损伤后人体内神经细胞死亡、水肿或缺血的方法。此外，还提供了一种用于阻止和/或逆转中枢神经系统损伤后人体神经变性进展的方法。上述方法包括黄体酮或合成孕激素给药机制的疗法。
• TEMPERATURE DETECTION MATERIAL, TEMPERATURE DETECTION INK USING SAME, TEMPERATURE INDICATOR, AND ARTICLE MANAGEMENT SYSTEM
  申请人：HITACHI INDUSTRIAL EQUIPMENT SYSTEMS CO., LTD.

  公开号：EP3614113A1

  公开（公告）日：2020-02-26

  A temperature detecting material comprises a first material containing a first temperature indicating material (temperature indicating material A) and a second material containing a second temperature indicating material (for example, temperature indicating material B), wherein the first temperature indicating material and the second temperature indicating material contain a leuco dye, a color developing agent, and a decoloring agent, and have a hysteresis characteristic in their color density-temperature curves, wherein the first temperature indicating material has a color developing temperature (Ta1 (Ta1A)) in a temperature increase process lower than a decoloring temperature (Td1 (Td1A)) in the temperature increase process, and turns to a non-crystalline state and is kept in a decoloring state when cooled down below the color developing temperature (Ta1) in the temperature increase process with a predetermined cooling speed or more after melting, wherein the second temperature indicating material, a color developing temperature (Ta2 (Ta2B)) is lower than a decoloring temperature (Td2 (Td2B)) in the temperature increase process, and wherein the color developing temperature (Ta1) in the temperature increase process is lower than the decoloring temperature (Td2) in the temperature increase process and the color developing temperature (Ta2) is lower than the color developing temperature (Ta1) in the temperature increase process.

  一种温度检测材料包括含有第一种温度指示材料（温度指示材料 A）的第一种材料和含有第二种温度指示材料（例如温度指示材料 B）的第二种材料，其中第一种温度指示材料和第二种温度指示材料含有一种白兰地染料、其中第一温度指示材料和第二温度指示材料含有一种白光染料、一种显色剂和一种脱色剂，它们的色密度-温度曲线具有滞后特性，其中第一温度指示材料在升温过程中的显色温度（Ta1 (Ta1A)）低于升温过程中的脱色温度（Td1 (Td1A)）、并在熔化后以预定的冷却速度冷却到升温过程中的显色温度 (Ta1) 以下时变成非结晶状态并保持脱色状态，其中第二温度指示材料的显色温度 (Ta2 (Ta2B)) 低于升温过程中的脱色温度 (Td2 (Td2B))、其中温度升高过程中的显色温度 (Ta1) 低于温度升高过程中的脱色温度 (Td2)，显色温度 (Ta2) 低于温度升高过程中的显色温度 (Ta1)。