6-methyl-N-prop-2-enylquinazolin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-methyl-N-prop-2-enylquinazolin-4-amine
• 化学式: C₁₂H₁₃N₃
• mdl: MFCD02081786
• 分子量: 199.25
• InChiKey: LPKJVEMSQKGOHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOUNDS AND METHODS FOR TREATMENT OF DIAMOND BLACKFAN ANEMIA
  申请人：THE CHILDREN'S MEDICAL CENTER CORPORATION

  公开号：US20200188402A1

  公开（公告）日：2020-06-18

  The present invention relates generally to methods for treatment of ribosomal disorders and ribosomopathy, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to methods for the use of a small-molecule autophagy modulator for treatment of ribosomal disorders and ribosomopathy. The invention also relates to small molecule drug discovery and methods of screening compositions to determine their effectiveness for treatment of ribosomal disorders and ribosomopathies.