6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-isochromene | 893776-29-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-isochromene
• CAS: 893776-29-9
• 化学式: C₂₀H₂₄O₆
• 分子量: 360.407
• InChiKey: YWGSMTPVPUXSJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3,4,5-三甲氧基苯甲醛 、 3,4-二甲氧基苯乙醇 在 对甲苯磺酸 作用下， 以 水 为溶剂， 反应 0.67h， 以94%的产率得到6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-isochromene
  参考文献：
  名称：

  水中的Oxa-Pictet-Spengler反应。一些（±）-1-芳基-6,7-二甲氧基异色满的合成

  摘要：

  摘要描述了一种酸催化的“ oxa-Pictet-Spengler反应在水上”反应，该反应导致合成各种1-芳基-6,7-二甲氧基异色满。水性化学物质是一种更清洁，有效，便宜且简单的合成方法。反应范围扩大到了硫杂-皮格特-斯宾格勒反应，得到了一些异硫氰酸盐。

  DOI：

  10.1016/j.cclet.2009.11.009

文献信息

• Methods of preventing or treating flavivirus virus infections and methods of inhibiting the entry of flvivirus, enterovirus or lentivirus into host cells
  申请人：City University of Hong Kong

  公开号：US11357771B2

  公开（公告）日：2022-06-14

  A method of preventing or treating a subject suffering from a flavivirus infection by administering an effective amount of berbamine or its analogue to the subject, berbamine has a structure of Formula (I), wherein the flavivirus infection is caused by Japanese encephalitis virus, Zika virus or Dengue virus. A method of inhibiting the entry of a flavivirus, an enterovirus and/or a lentivirus into host cells includes contacting the host cells with an effective amount of berbamine of its analogue, berbamine has a structure of Formula (I), wherein the flavivirus is Japanese encephalitis virus, Zika virus or Dengue virus.

  一种通过向受试者施用有效量的小檗胺或其类似物来预防或治疗黄病毒感染的方法，小檗胺具有式(I)的结构，其中黄病毒感染是由日本脑炎病毒、寨卡病毒或登革病毒引起的。一种抑制黄病毒、肠道病毒和/或慢病毒进入宿主细胞的方法，包括使宿主细胞与有效量的伯胺或其类似物接触，伯胺具有式（I）的结构，其中黄病毒是日本脑炎病毒、寨卡病毒或登革病毒。
• METHODS OF PREVENTING OR TREATING FLAVIVIRUS VIRUS INFECTIONS AND METHODS OF INHIBITING THE ENTRY OF FLVIVIRUS, ENTEROVIRUS OR LENTIVIRUS INTO HOST CELLS
  申请人：City University of Hong Kong

  公开号：US20210060002A1

  公开（公告）日：2021-03-04

  A method of preventing or treating a subject suffering from a flavivirus infection by administering an effective amount of berbamine or its analogue to the subject, berbamine has a structure of Formula (I), wherein the flavivirus infection is caused by Japanese encephalitis virus, Zika virus or Dengue virus. A method of inhibiting the entry of a flavivirus, an enterovirus and/or a lentivirus into host cells includes contacting the host cells with an effective amount of berbamine of its analogue, berbamine has a structure of Formula (I), wherein the flavivirus is Japanese encephalitis virus, Zika virus or Dengue virus.
• [EN] USE OF BERBAMINE OR ITS ANALOGUE FOR PREVENTING OR TREATING RNA VIRUS INFECTION<br/>[FR] UTILISATION DE BERBAMINE OU DE SON ANALOGUE POUR LA PRÉVENTION OU LE TRAITEMENT D'UNE INFECTION PAR LE VIRUS DE L'ARN
  申请人：UNIV CITY HONG KONG

  公开号：WO2021043234A1

  公开（公告）日：2021-03-11

  Provided herein is a method of preventing or treating a subject suffering from a flavivirus infection by administering an effective amount of berbamine or its analogue to the subject, berbamine has a structure of Formula (I), wherein the flavivirus infection is caused by Japanese encephalitis virus, Zika virus or Dengue virus, and a method of inhibiting the entry of a flavivirus, an enterovirus and/or a lentivirus into host cells, comprising contacting the host cells with an effective amount of berbamine of its analogue, berbamine has a structure of Formula (I), wherein the flavivirus is Japanese encephalitis virus, Zika virus or Dengue virus. Also provided is a method of preventing or treating a subject suffering from a coronavirus, particularly the coronavirus is SARS-CoV-2 or MERS-CoV, a method of inhibiting the entry of a coronavirus into host cells, as well as use of berbamine or its analogue in the preparation of a medicament for preventing or treating a flavivirus infection, enterovirus infection, lentivirus infection or coronavirus infection.
• Oxa-Pictet–Spengler reaction in water. Synthesis of some (±)-1-aryl-6,7-dimethoxyisochromans
  作者：Aamer Saeed

  DOI：10.1016/j.cclet.2009.11.009

  日期：2010.3

  Abstract An acid catalyzed oxa-Pictet–Spengler reaction ‘on water’ leading to the synthesis of a variety of 1-aryl-6,7-dimethoxyisochromans is described. The aqueous chemistry is a much cleaner, efficient, cheaper and simple method for synthesis. The scope of reactions was extended to thia-Pictet–Spengler reaction to afford the some isothiochromans.

  摘要描述了一种酸催化的“ oxa-Pictet-Spengler反应在水上”反应，该反应导致合成各种1-芳基-6,7-二甲氧基异色满。水性化学物质是一种更清洁，有效，便宜且简单的合成方法。反应范围扩大到了硫杂-皮格特-斯宾格勒反应，得到了一些异硫氰酸盐。