2,2,2-trifluoro-N-(4-thiophen-2-yl-1,3-thiazol-2-yl)acetamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,2,2-trifluoro-N-(4-thiophen-2-yl-1,3-thiazol-2-yl)acetamide
• 化学式: C₉H₅F₃N₂OS₂
• 分子量: 278.3
• InChiKey: JVZISHUHKCEUER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  98.5
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF
  申请人：ASTELLAS PHARMA INC.

  公开号：US20170197955A1

  公开（公告）日：2017-07-13

  [Problem] To provide a compound which is useful as an active ingredient for a pharmaceutical composition for preventing or treating urine storage dysfunction, voiding dysfunction, lower urinary tract dysfunction, and the like. [Means for Solution] The present inventors have found that a thiazole derivative substituted with pyrazinylcarbonylamino at the 2-position is an excellent muscarinic M 3 receptor-positive allosteric modulator and is expected as an agent for preventing or treating bladder/urinary tract diseases associated with bladder contractions via a muscarinic M 3 receptor, thereby completing the present invention. 2-Acylaminothiazole derivative or a salt thereof of the present invention is expected as an agent for preventing or treating bladder/urinary tract diseases associated with bladder contractions via a muscarinic M 3 receptor, for example voiding dysfunction such as underactive bladder.