trans-2-Chloro-4-carboxymethylenebut-2-en-1,4-olide | 22752-93-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: trans-2-Chloro-4-carboxymethylenebut-2-en-1,4-olide
• 英文别名: (2Z)-2-(4-chloro-5-oxofuran-2-ylidene)acetic acid
• CAS: 22752-93-8
• 化学式: C₆H₃ClO₄
• 分子量: 174.54
• InChiKey: ADSGHWJRPOXXTD-IHWYPQMZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ANTIBODIES WITH FUNCTIONAL DOMAINS IN THE ELBOW REGION BETWEEN VARIABLE AND CONSTANT DOMAIN
  申请人：Institute for Research in Biomedicine

  公开号：EP3661962A1

  公开（公告）日：2020-06-10
• ENGINEERING B LYMPHOCYTES BY UTILIZING ENDOGENOUS ACTIVATION-INDUCED CYTIDINE DEAMINASE
  申请人：Institute for Research in Biomedicine

  公开号：EP3802841A1

  公开（公告）日：2021-04-14
• NUCLEIC ACIDS AND PROTEINS AND METHODS FOR MAKING AND USING THEM
  申请人：BP Corporation North America Inc.

  公开号：US20150240226A1

  公开（公告）日：2015-08-27

  The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. Polypeptides, including enzymes and antibodies, and nucleic acids of the invention can be used in industrial, experimental, food and feed processing, nutritional and pharmaceutical applications, e.g., for food and feed supplements, colorants, neutraceuticals, cosmetic and pharmaceutical needs.
• [EN] METHODS FOR THE IDENTIFICATION OF BIFUNCTIONAL COMPOUNDS<br/>[FR] PROCÉDÉS D'IDENTIFICATION DE COMPOSÉS BIFONCTIONNELS
  申请人：ITARA THERAPEUTICS

  公开号：WO2017187183A1

  公开（公告）日：2017-11-02

  The present disclosure provides bifunctional compounds including a polypeptide targeting moiety conjugated to a small molecule in a site-specific manner both of which bind to the same target protein resulting in potent and specific binding characteristics and methods of identifying such compounds.
• [EN] ANTIBODIES WITH FUNCTIONAL DOMAINS IN THE ELBOW REGION<br/>[FR] ANTICORPS À DOMAINES FONCTIONNELS DANS LA RÉGION DE COUDE
  申请人：INST RES BIOMEDICINE

  公开号：WO2019024979A1

  公开（公告）日：2019-02-07

  The present invention provides engineered antibodies and antigen binding fragments, in which an additional functional domain is inserted into the elbow region of the antibody or antigen binding fragment. The present invention also provides nucleic acid molecules, such as vectors, encoding such antibodies and antigen binding fragments, host cells and compositions comprising such antibodies, antigen binding fragments or nucleic acid molecules and uses thereof. For example a multispecific antibody format is provided, in which an additional binding site (specificity) is inserted into the elbow region of an antibody or antigen binding fragment.