Hexyl-((S)-1-phenyl-ethyl)-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Hexyl-((S)-1-phenyl-ethyl)-amine
• 英文别名: N-[(1S)-1-phenylethyl]hexan-1-amine
• 化学式: C₁₄H₂₃N
• 分子量: 205.343
• InChiKey: RGSPUCRWIKFBND-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (S)-N-pentylmethylidene-1-phenylethylamine 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以9.85 g的产率得到Hexyl-((S)-1-phenyl-ethyl)-amine
  参考文献：
  名称：

  Solid-phase supported chiral lithium amides used in deprotonation reactions

  摘要：

  The lithium salt of polymer supported phenylethyl amine showed surprisingly high enantioselectivity. in the asymmetric deprotonation reaction of cyclohexene oxide. The polymer supported chiral lithium amide base also proved to be more reactive compared to the free chiral lithium amide base. This is a new insight in the development and mechanism of chiral lithium amide bases used in asymmetric reactions. (C) 2003 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(03)00280-5

文献信息

• Pyridine and pyridimine compounds as PI3K-gamma inhibitors
  申请人：Incyte Corporation

  公开号：US11352340B2

  公开（公告）日：2022-06-07

  The present disclosure provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that modulate the activity of phosphoinositide 3-kinases-gamma (PI3Kγ) and are useful in the treatment of diseases related to the activity of PI3Kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

  本公开提供了式 I 的化合物或其药学上可接受的盐，它们能调节磷酸肌醇 3-激酶-γ（PI3Kγ）的活性，可用于治疗与 PI3Kγ 活性有关的疾病，例如包括自身免疫性疾病、癌症、心血管疾病和神经退行性疾病。
• Solid-phase supported chiral lithium amides used in deprotonation reactions
  作者：Anna Johansson、Peter Abrahamsson、Öjvind Davidsson

  DOI：10.1016/s0957-4166(03)00280-5

  日期：2003.5

  The lithium salt of polymer supported phenylethyl amine showed surprisingly high enantioselectivity. in the asymmetric deprotonation reaction of cyclohexene oxide. The polymer supported chiral lithium amide base also proved to be more reactive compared to the free chiral lithium amide base. This is a new insight in the development and mechanism of chiral lithium amide bases used in asymmetric reactions. (C) 2003 Published by Elsevier Science Ltd.