cholesteryl 6-aminohexylcarbamate hydrochloride | 1226805-77-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: cholesteryl 6-aminohexylcarbamate hydrochloride
• 英文别名: [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-(6-aminohexyl)carbamate;hydrochloride
• CAS: 1226805-77-1
• 化学式: C₃₄H₆₀N₂O₂*ClH
• 分子量: 565.324
• InChiKey: QNGBKPKQFCTBNZ-FRLYOMOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.06
• 重原子数：
  39
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  64.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-Boc-1,6-己二胺 、 胆固醇甲酰氯 在 盐酸 、 三乙胺 作用下， 以 anhydride dichloromethane 、 乙酸乙酯 为溶剂， 生成 cholesteryl 6-aminohexylcarbamate hydrochloride
  参考文献：
  名称：

  HYALURONIC ACID DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF

  摘要：

  本发明提供了一种含有疏水基引入的透明质酸衍生物，其包括至少一个由式(I)表示的重复单元，其中R1、R2、R3、R4、Z、n、Ra、Y和X1如规范中所定义。

  公开号：

  US20110212901A1

文献信息

• HYALURONIC ACID DERIVATIVE HAVING AMINO ACID AND STERYL GROUP INTRODUCED THEREINTO
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：US20150231268A1

  公开（公告）日：2015-08-20

  The present invention provides a hyaluronic acid derivative containing a disaccharide unit represented by formula (I) or formula (I) and (II), and a complex containing the hyaluronic acid derivative and a drug.

  本发明提供了一种含有由化学式（I）或化学式（I）和（II）表示的二糖单元的透明质酸衍生物，以及含有该透明质酸衍生物和药物的复合物。
• HYALURONIC ACID DERIVATIVE MODIFIED WITH POLY(ETHYLENE GLYCOL)
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：EP3712181A1

  公开（公告）日：2020-09-23

  The present invention provides hyaluronic acid derivatives including one or more of each of repeating units represented by the formulae (Ia), (Ib), and (Ic) in which certain cationic sites, certain hydrophobic sites, and certain hydrophilic sites have been introduced. In addition, the present invention provides complexes of the hyaluronic acid derivatives with a drug and pharmaceutical compositions including the hyaluronic acid derivatives, in particular, complexes of the hyaluronic acid derivatives with a drug.

  本发明提供了透明质酸衍生物，包括式(Ia)、(Ib)和(Ic)所代表的重复单元中的每个单元中的一个或多个，其中引入了某些阳离子位点、某些疏水位点和某些亲水位点。此外，本发明还提供了透明质酸衍生物与药物的复合物以及包括透明质酸衍生物的药物组合物，特别是透明质酸衍生物与药物的复合物。
• HYALURONIC ACID DERIVATIVE COMPOSITION, PHARMACEUTICAL COMPOSITION AND HYALURONIC ACID DERIVATIVE-DRUG CONJUGATE COMPOSITION
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP4101466A1

  公开（公告）日：2022-12-14

  Provided are: a hyaluronic acid derivative composition that comprises (A) a hyaluronic acid derivative having a steryl group introduced therein; and (B) a polar group-containing compound having at least one functional group selected from the group consisting of hydroxy group, carboxy group, amino group, amide group, carbamate group, urea group and thiol group, wherein the steryl group has been introduced at a ratio of 0.1% or more and less than 35% relative to the hyaluronic acid derivative (A); a pharmaceutical composition that contains the hyaluronic acid derivative composition as a carrier; and a hyaluronic acid derivative-drug conjugate composition wherein, in the hyaluronic acid derivative composition, one or more drugs are conjugated to the hyaluronic acid derivative (A).

  提供了一种透明质酸衍生物组合物，该组合物包含(A)其中引入了固醇基的透明质酸衍生物；和(B)具有至少一个选自羟基、羧基、氨基、酰胺基、氨基甲酸酯基、脲基和硫醇基的官能团的含极性基团化合物，其中固醇基的引入比例为透明质酸衍生物(A)的0.1%或更高，相对于透明质酸衍生物（A）小于35%；一种药物组合物，其中包含作为载体的透明质酸衍生物组合物；以及一种透明质酸衍生物-药物共轭组合物，其中在透明质酸衍生物组合物中，一种或多种药物与透明质酸衍生物（A）共轭。
• HYALURONIC ACID DERIVATIVE MODIFIED WITH POLYETHYLENE GLYCOL
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：US20210371548A1

  公开（公告）日：2021-12-02

  The present invention provides hyaluronic acid derivatives including one or more of each of repeating units represented by the formulae (Ia), (Ib), and (Ic) in which certain cationic sites, certain hydrophobic sites, and certain hydrophilic sites have been introduced. In addition, the present invention provides complexes of the hyaluronic acid derivatives with a drug and pharmaceutical compositions including the hyaluronic acid derivatives, in particular, complexes of the hyaluronic acid derivatives with a drug.
• US8759322B2
  申请人：——

  公开号：US8759322B2

  公开（公告）日：2014-06-24