5-(3,4-Dihydroxybenzylidene)-3-methyl-2-thioxo-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-(3,4-Dihydroxybenzylidene)-3-methyl-2-thioxo-1,3-thiazolidin-4-one
• 英文别名: (5E)-5-[(3,4-dihydroxyphenyl)methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
• 化学式: C₁₁H₉NO₃S₂
• 分子量: 267.3
• InChiKey: KFYKNLMDHKABIQ-WEVVVXLNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• COMPOSITIONS AND METHODS FOR CONTROLLING NEURONAL EXCITATION
  申请人：Peterson Randall

  公开号：US20140330195A1

  公开（公告）日：2014-11-06

  Embodiments of the technology described herein relate, at least in part, to methods of modulating the activity of a neuron by contacting the neuron with a photo-sensitive TrpA1 agonist and then illuminating the neuron with electromagnetic radiation. Also described herein are photo-sensitive TrpA1 agonists.
• US9486447B2
  申请人：——

  公开号：US9486447B2

  公开（公告）日：2016-11-08
• [EN] INHIBITORS OF EPSTEIN BARR VIRUS NUCLEAR ANTIGEN 1<br/>[FR] INHIBITEURS DE L'ANTIGENE NUCLEAIRE 1 DU VIRUS EPSTEIN-BARR
  申请人：BRIGHAM & WOMENS HOSPITAL

  公开号：WO2007002587A2

  公开（公告）日：2007-01-04

  [EN] The invention relates to a high throughput assay and methods for detecting inhibitors. The invention also relates to the inhibitors identified by the assay methods, and methods of using the inhibitors to treat and prevent disease.
  [FR] L'invention porte sur un dosage à haut débit et sur des procédés permettant de détecter des inhibiteurs. L'invention concerne également les inhibiteurs identifiés selon lesdits procédés, et des procédés d'utilisation des inhibiteurs dans le traitement et la prévention de maladies.
• [EN] COMPOSITIONS AND METHODS FOR CONTROLLING NEURONAL EXCITATION<br/>[FR] COMPOSITIONS ET PROCÉDÉS DESTINÉS À RÉGULER L'EXCITATION NEURONALE
  申请人：GEN HOSPITAL CORP

  公开号：WO2012174049A2

  公开（公告）日：2012-12-20

  Embodiments of the technology described herein relate, at least in part, to methods of modulating the activity of a neuron by contacting the neuron with a photo-sensitive TrpA1 agonist and then illuminating the neuron with electromagnetic radiation. Also described herein are photo-sensitive TrpA1 agonists.