Dicyclohexyl-[(R)-1-((S)-1-phenyl-ethyl)-azetidin-2-yl]-methanol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Dicyclohexyl-[(R)-1-((S)-1-phenyl-ethyl)-azetidin-2-yl]-methanol
• 英文别名: dicyclohexyl-[(2R)-1-[(1S)-1-phenylethyl]azetidin-2-yl]methanol
• 化学式: C₂₄H₃₇NO
• 分子量: 355.564
• InChiKey: CKNQGYBCGDCJJQ-WMZHIEFXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  methyl (2R,1'S)-1-(1'-methyl)benzylazetidine-2-carboxylate 、 alkaline earth salt of/the/ methylsulfuric acid 以 乙醚 为溶剂， 反应 2.0h， 以66%的产率得到Dicyclohexyl-[(R)-1-((S)-1-phenyl-ethyl)-azetidin-2-yl]-methanol
  参考文献：
  名称：

  Azetidine based ligands in boron catalyzed asymmetric Diels-Alder reactions

  摘要：

  The preparation of a new class of azetidine-based auxiliaries and their selectivity in the BBr3 catalyzed Diets-Alder reaction is described. The results are compared with a similar proline-derived ligand and a known prolinol auxiliary. Results show that selectivities are highly dependent on the dienophile and the substituent of the chiral auxiliary. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00204-x

文献信息

• Azetidine based ligands in boron catalyzed asymmetric Diels-Alder reactions
  作者：Wim A.J. Starmans、Richard W.A. Walgers、Lambertus Thijs、René de Gelder、Jan M.M. Smits、Binne Zwanenburg

  DOI：10.1016/s0040-4020(98)00204-x

  日期：1998.5

  The preparation of a new class of azetidine-based auxiliaries and their selectivity in the BBr3 catalyzed Diets-Alder reaction is described. The results are compared with a similar proline-derived ligand and a known prolinol auxiliary. Results show that selectivities are highly dependent on the dienophile and the substituent of the chiral auxiliary. (C) 1998 Elsevier Science Ltd. All rights reserved.