4-[(5-{2-Hydroxy-5-nitrophenyl}-2-furyl)methylene]-1-phenyl-3,5-pyrazolidinedione

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-[(5-{2-Hydroxy-5-nitrophenyl}-2-furyl)methylene]-1-phenyl-3,5-pyrazolidinedione
• 英文别名: (4Z)-4-[[5-(2-hydroxy-5-nitrophenyl)furan-2-yl]methylidene]-1-phenylpyrazolidine-3,5-dione
• 化学式: C20H13N3O6
• 分子量: 391.3
• InChiKey: DJUUZXKLCIZGTG-WJDWOHSUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• US9216180B2
  申请人：——

  公开号：US9216180B2

  公开（公告）日：2015-12-22
• [EN] PHARMACEUTICAL COMPOSITIONS AND TREATMENT OF GENETIC DISEASES ASSOCIATED WITH NONSENSE MEDIATED RNA DECAY<br/>[FR] COMPOSITIONS PHARMACEUTIQUE ET TRAITEMENT DE MALADIES GÉNÉTIQUES ASSOCIÉES À UNE DÉSINTÉGRATION D'ARN À MÉDIATION NON-SENS
  申请人：UNIV NEW YORK

  公开号：WO2014055644A2

  公开（公告）日：2014-04-10

  The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating a genetic disease caused by premature termination codons, or other conditions that render messenger ribonucleic acid (mRNA) susceptible to nonsense mediated RNA decay, in a subject. Also disclosed is a method of inhibiting nonsense mediated RNA decay and/or induction of autophagy. The present invention also relates to a method of identifying inhibitors of nonsense mediated RNA decay and/or inducing autophagy. The present invention further relates to a method of inhibiting nonsense mediated RNA decay and/or induction of autophagy in a subject.