(S)-6-(4-fluorophenyl)-1-((S)-2-methoxy-methylpyrrolidin-1-yl)piperidin-2-one | 1394905-61-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (S)-6-(4-fluorophenyl)-1-((S)-2-methoxy-methylpyrrolidin-1-yl)piperidin-2-one
• 英文别名: (6S)-6-(4-fluorophenyl)-1-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]piperidin-2-one
• CAS: 1394905-61-3
• 化学式: C₁₇H₂₃FN₂O₂
• 分子量: 306.38
• InChiKey: JKSKBNNCBRQDTI-HOTGVXAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (S)-6-(4-fluorophenyl)-1-((S)-2-methoxy-methylpyrrolidin-1-yl)piperidin-2-one 在 magnesium bis(monoperoxyphthalate)hexahydrate 作用下， 以 甲醇 为溶剂， 以85%的产率得到(S)-6-(4-fluorophenyl)piperidin-2-one
  参考文献：
  名称：

  Alternative strategies for the stereoselective synthesis of enantioenriched 6-arylated piperidin-2-ones

  摘要：

  Two alternative synthetic approaches to a variety of enantioenriched 6-arylated piperidin-2-ones have been developed. The first one is based on the hydrogenation of suitably arylated chiral cyclic enehydrazides. The second approach relies on the asymmetric catalytic hydrogenation of the corresponding N-alkylated precursors. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2012.06.024
• 作为产物：
  描述：

  (S)-1-amino-2-(methoxymethyl)pyrrolidine 在 四(三苯基膦)钯 、 palladium 10% on activated carbon 、 甲酸铵 、 双(三甲基硅烷基)氨基钾 、 sodium carbonate 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 、 甲苯 为溶剂， 反应 12.5h， 生成 (S)-6-(4-fluorophenyl)-1-((S)-2-methoxy-methylpyrrolidin-1-yl)piperidin-2-one
  参考文献：
  名称：

  Alternative strategies for the stereoselective synthesis of enantioenriched 6-arylated piperidin-2-ones

  摘要：

  Two alternative synthetic approaches to a variety of enantioenriched 6-arylated piperidin-2-ones have been developed. The first one is based on the hydrogenation of suitably arylated chiral cyclic enehydrazides. The second approach relies on the asymmetric catalytic hydrogenation of the corresponding N-alkylated precursors. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2012.06.024

文献信息

• Alternative strategies for the stereoselective synthesis of enantioenriched 6-arylated piperidin-2-ones
  作者：Romain Sallio、Stéphane Lebrun、Francine Agbossou-Niedercorn、Christophe Michon、Eric Deniau

  DOI：10.1016/j.tetasy.2012.06.024

  日期：2012.7

  Two alternative synthetic approaches to a variety of enantioenriched 6-arylated piperidin-2-ones have been developed. The first one is based on the hydrogenation of suitably arylated chiral cyclic enehydrazides. The second approach relies on the asymmetric catalytic hydrogenation of the corresponding N-alkylated precursors. (C) 2012 Elsevier Ltd. All rights reserved.