3'-Amino-3'-desoxyadenosin-5'-monophosphat | 4360-05-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 3'-Amino-3'-desoxyadenosin-5'-monophosphat
• 英文别名: 3'-Amino-3'-deoxyadenin-5'-phosphat；3'-amino-3'-deoxy-[5']adenylic acid；3'-Amino-3'-deoxyadenosine 5'-(dihydrogen phosphate)；[(2S,3S,4R,5R)-3-amino-5-(6-aminopurin-9-yl)-4-hydroxyoxolan-2-yl]methyl dihydrogen phosphate
• CAS: 4360-05-8
• 化学式: C₁₀H₁₅N₆O₆P
• 分子量: 346.239
• InChiKey: WIVGZDLLXCRANL-QYYRPYCUSA-N

物化性质

• 沸点：
  780.4±70.0 °C(Predicted)
• 密度：
  2.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -6.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  192
• 氢给体数：
  5
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  3-氨基-d-腺苷酸 在 三正丁胺 、 三丁基焦磷酸铵 、 三氟乙酸 、 三氯氧磷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.16h， 生成 3'-Amino-3'-desoxyadenosin-5'-monophosphat
  参考文献：
  名称：

  Morr, Michael; Wray, Victor, Angewandte Chemie, 1994, vol. 106, # 13, p. 1439 - 1441

  摘要：

  DOI：

文献信息

• METHOD FOR PRODUCING DIVERSE LIBRARIES OF ENCODED POLYPEPTIDES
  申请人：——

  公开号：US20020031762A1

  公开（公告）日：2002-03-14

  tRNA analogues which comprise a tRNA, such as tRNA phe ; an amino acid moiety which acts as an acceptor substrate, but not as a donor substrate, for ribosome-directed peptidyl transfer and, thus, is stably linked to the acceptor stem of the tRNA; and a reactive or activatible moiety near or within the anticodon stem loop of the tRNA that can medidate the covalent coupling of the tRNA analogue to mRNA. Also described are polypeptide-tRNA analogue-mRNA fusions; libraries of encoded polypeptides; methods of producing and screening the libraries; and target members and their uses.

  由 tRNA 组成的 tRNA 类似物，如 tRNA 雉 的受体底物，而不是供体底物，从而与 tRNA 的受体茎稳定连接；以及在 tRNA 的反密码子茎环附近或内部的活性或活化相容分子，该分子可介导 tRNA 类似物与 mRNA 的共价偶联。还描述了多肽-tRNA 类似物-mRNA 融合；编码多肽文库；生产和筛选文库的方法；以及目标成员及其用途。
• Method for producing diverse libraries of encoded polypeptides
  申请人：Whitehead Institute for Biomedical Research

  公开号：US20030022213A1

  公开（公告）日：2003-01-30

  tRNA analogues which comprise a tRNA, such as tRNA phe ; an amino acid moiety which acts as an acceptor substrate, but not as a donor substrate, for ribosome-directed peptidyl transfer and, thus, is stably linked to the acceptor stem of the tRNA; and a reactive or activatible moiety near or within the anticodon stem loop of the tRNA that can medidate the covalent coupling of the tRNA analogue to mRNA. Also described are polypeptide-tRNA analogue-mRNA fusions; libraries of encoded polypeptides; methods of producing and screening the libraries; and target members and their uses.

  由 tRNA 组成的 tRNA 类似物，如 tRNA 雉 的受体底物，而不是供体底物，从而与 tRNA 的受体茎稳定连接；以及在 tRNA 的反密码子茎环附近或内部的活性或活化相容分子，该分子可介导 tRNA 类似物与 mRNA 的共价偶联。还描述了多肽-tRNA 类似物-mRNA 融合；编码多肽文库；生产和筛选文库的方法；以及目标成员及其用途。
• Bifunctional tRNA for in vitro selection
  申请人：Whitehead Institute for Biomedical Research

  公开号：US20040038273A1

  公开（公告）日：2004-02-26

  Disclosed are tRNA analogues which comprise a tRNA, such as tRNA phe ; a nonstandard amino acid moiety which acts as an acceptor substrate, but not as a donor substrate, for ribosome-directed nonstandard polymer transfer and, thus, is stably linked to the acceptor stem of the tRNA; and a reactive or activatible moiety near or within the anticodon stem loop of the tRNA that can medidate the covalent coupling of the tRNA analogue to mRNA. Also disclosed are nonstandard polymer-tRNA analogue-mRNA fusions; libraries of encoded nonstandard polymers; methods of producing and screening the libraries; and target members and their uses.

  所公开的 tRNA 类似物包括 tRNA，如 tRNA 雉 非标准氨基酸分子，该分子可作为核糖体定向非标准聚合物转移的受体底物而非供体底物，因此可稳定地连接到 tRNA 的受体茎上；以及在 tRNA 的反密码子茎环附近或内部的活性或活化相容分子，该分子可介导 tRNA 类似物与 mRNA 的共价偶联。还公开了非标准聚合物-tRNA 类似物-mRNA 融合体；编码的非标准聚合物文库；生产和筛选文库的方法；以及目标成员及其用途。
• US6440695B1
  申请人：——

  公开号：US6440695B1

  公开（公告）日：2002-08-27
• Morr, Michael; Wray, Victor, Angewandte Chemie, 1994, vol. 106, # 13, p. 1439 - 1441
  作者：Morr, Michael、Wray, Victor

  DOI：——

  日期：——