6,7-dimethoxy-3-propyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6,7-dimethoxy-3-propyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one
• 英文别名: 6,7-dimethoxy-3-propyl-2-sulfanylidene-1H-quinazolin-4-one
• 化学式: C₁₃H₁₆N₂O₃S
• 分子量: 280.34
• InChiKey: VFMWHWROUGBLFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  82.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Combination therapy to enhance the anticancer efficacy of platinum drugs
  申请人：University of Pittsburgh-of the Commonwealth System of Higher Education

  公开号：US10478437B2

  公开（公告）日：2019-11-19

  The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death. It is based, at least in part, on the discovery that in platinum drug-resistant cell lines, certain compounds, together with a second antiproliferative agent (e.g., cisplatin), act synergistically to promote apoptosis. Accordingly, the present invention provides for novel anticancer strategies.

  本发明涉及减少细胞增殖和/或促进细胞死亡的组合物和方法。本发明至少部分基于以下发现：在铂类药物耐药细胞系中，某些化合物与第二种抗增殖剂（如顺铂）一起发挥协同作用，促进细胞凋亡。因此，本发明提供了新的抗癌策略。
• COMBINATION THERAPY TO ENHANCE THE ANTICANCER EFFICACY OF PLATINUM DRUGS
  申请人：University of Pittsburgh - of the Commonwealth System of Higher Education

  公开号：US20170095478A1

  公开（公告）日：2017-04-06

  The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death. It is based, at least in part, on the discovery that in platinum drug-resistant cell lines, certain compounds, together with a second antiproliferative agent (e.g., cisplatin), act synergistically to promote apoptosis. Accordingly, the present invention provides for novel anticancer strategies.