2-(2,4-dichlorophenyl)-3-(4-methylphenyl)quinazolin-4(3H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(2,4-dichlorophenyl)-3-(4-methylphenyl)quinazolin-4(3H)-one
• 英文别名: 2-(2,4-dichlorophenyl)-3-(4-methylphenyl)-4(3H)-quinazolinone；2-(2,4-dichlorophenyl)-3-(4-methylphenyl)quinazolin-4-one
• 化学式: C₂₁H₁₄Cl₂N₂O
• 分子量: 381.261
• InChiKey: KXHDFSJWWFJBPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Mitotic kinesin inhibitors
  申请人：Arrington L. Kenneth

  公开号：US20070060601A1

  公开（公告）日：2007-03-15

  The present invention relates to 2,3-diarylquinazolinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

  本发明涉及对细胞增殖性疾病有用的2,3-二芳基喹唑啉酮化合物，用于治疗与KSP动力蛋白活性相关的疾病，并抑制KSP动力蛋白。该发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
• MITOTIC KINESIN INHIBITORS
  申请人：Merck & Co., Inc.

  公开号：EP1696927A2

  公开（公告）日：2006-09-06
• EP1696927A4
  申请人：——

  公开号：EP1696927A4

  公开（公告）日：2007-10-31
• [EN] MITOTIC KINESIN INHIBITORS<br/>[FR] INHIBITEURS MITOTIQUES DE LA KINESINE
  申请人：MERCK & CO INC

  公开号：WO2005065183A2

  公开（公告）日：2005-07-21

  The present invention relates to 2,3-diarylquinazolinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.