1-tert-butyl-6-(4-methylbenzoylamino)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid ethylamide | 915726-23-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 1-tert-butyl-6-(4-methylbenzoylamino)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid ethylamide
• 英文别名: 1h-Pyrrolo[2,3-b]pyridine-3-carboxamide,1-(1,1-dimethylethyl)-n-ethyl-6-[(4-methylbenzoyl)amino]-；1-tert-butyl-N-ethyl-6-[(4-methylbenzoyl)amino]pyrrolo[2,3-b]pyridine-3-carboxamide
• CAS: 915726-23-7
• 化学式: C₂₂H₂₆N₄O₂
• 分子量: 378.474
• InChiKey: LQXIRHKLLMPILW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-tert-butyl-6-(4-methylbenzoylamino)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid 、 乙胺 在 三乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以32%的产率得到1-tert-butyl-6-(4-methylbenzoylamino)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid ethylamide
  参考文献：
  名称：

  WO2008/67121

  摘要：

  公开号：

文献信息

• Methods and compositions for improving cognition
  申请人：Barbosa Joseph

  公开号：US20060258691A1

  公开（公告）日：2006-11-16

  This invention encompasses methods of improving cognitive performance and of treating, preventing and managing various diseases and disorders, such as Alzheimer's disease, autism, cognitive disorders, dementia, learning disorders, and short- and long-term memory loss.

  这项发明涵盖了改善认知表现的方法，以及治疗、预防和管理各种疾病和障碍，如阿尔茨海默病、自闭症、认知障碍、痴呆症、学习障碍以及短期和长期记忆丧失。
• Pyrrolopyridine, pyrrolopyrimidine and pyrazolopyridine compounds, compositions comprising them, and methods of their use
  申请人：Fink Anne Cynthia

  公开号：US20070049608A1

  公开（公告）日：2007-03-01

  Disclosed are pyrrolopyridine, pyrrolopyrimidine and pyrazolopyridine compounds, compositions comprising them, and methods of their use.

  本发明涉及吡咯吡啶、吡咯嘧啶和吡唑吡啶化合物，包括它们的组合物和使用方法。
• Methods of Treating Cognitive Impairment and Dementia
  申请人：Barbosa Joseph

  公开号：US20080153811A1

  公开（公告）日：2008-06-26

  This invention relates to methods for treating, managing and preventing cognitive impairment associated with various diseases and disorders, age-associated memory impairment, and dementia.

  本发明涉及用于治疗、管理和预防与各种疾病和障碍相关的认知障碍、与年龄相关的记忆障碍和痴呆症的方法。
• METHODS OF TREATING SCHIZOPHRENIA
  申请人：Barbosa Joseph

  公开号：US20090306100A1

  公开（公告）日：2009-12-10

  This invention relates to methods for treating, managing and preventing cognitive impairment associated with various diseases and disorders, age-associated memory impairment, and dementia.

  本发明涉及用于治疗、管理和预防与各种疾病和障碍相关的认知障碍，年龄相关的记忆障碍和痴呆症的方法。
• [EN] METHODS AND COMPOSITIONS FOR IMPROVING COGNITION<br/>[FR] PROCEDES ET COMPOSITIONS D'AMELIORATION DE LA COGNITION
  申请人：LEXICON GENETICS INC

  公开号：WO2006124897A2

  公开（公告）日：2006-11-23

  [EN] This invention encompasses methods of improving cognitive performance and of treating, preventing and managing various diseases and disorders, such as Alzheimer's disease, autism, cognitive disorders, dementia, learning disorders, and short- and long-term memory loss.
  [FR] L'invention concerne des procédés d'amélioration des performances cognitives et de traitement, prévention et gestion de divers troubles et maladies, comme la maladie d'Alzheimer, l'autisme, les troubles cognitifs, la démence, les troubles d'apprentissage et la perte de mémoire court et long terme.