2-amino-N-cyclopentyl-1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-amino-N-cyclopentyl-1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide
• 英文别名: 2-amino-N-cyclopentyl-1-(3-methoxypropyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide
• 化学式: C₂₀H₂₅N₅O₂
• 分子量: 367.4
• InChiKey: VNOFYGGJZCEPAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  95.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• PD-1 SIGNAL INHIBITOR COMBINATION THERAPY
  申请人：Kyoto University

  公开号：EP3388084A1

  公开（公告）日：2018-10-17

  A novel therapeutic strategy for the anti-PD-1 antibody therapy is provided. A pharmaceutical composition which comprises at least one substance selected from the group consisting of the following (i) to (iii) and is administered before, after or simultaneously with the administration of a PD-1 signal inhibitor: (i) ROS generators and substances that regulate downstream signaling pathways thereof, (ii) substances exhibiting an uncoupling effect and substances that regulate downstream signaling pathways thereof, and (iii) amino acids.

  本研究提供了一种新型的抗PD-1抗体治疗策略。 一种药物组合物，它包含至少一种选自以下(i)至(iii)组的物质，并在给药 PD-1 信号抑制剂之前、之后或同时给药： (i) ROS 生成物和调节其下游信号通路的物质、 (ii) 具有解偶联效应的物质和调节其下游信号通路的物质，以及 (iii) 氨基酸。
• METHODS AND COMPOSITIONS FOR MODULATING TAU LEVELS
  申请人：The J. David Gladstone Institutes

  公开号：EP2496594A1

  公开（公告）日：2012-09-12
• Use of SIRT1 Activators or Inhibitors to Modulate an Immune Response
  申请人：VERDIN ERIC M.

  公开号：US20100330114A1

  公开（公告）日：2010-12-30

  The present disclosure provides a method of increasing an immune response in an individual, the method involving administering to an individual in need thereof an inhibitor of SIRT1. The present disclosure provides a method of reducing an immune response, e.g., to treat chronic immune hyperactivity, the method generally involving administering to an individual in need thereof an activator of SIRT1. The present disclosure provides a method of modulating activation and differentiation of CD4 + T cells.
• Methods and Compositions for Modulating Tau Levels
  申请人：Gan Li

  公开号：US20120225864A1

  公开（公告）日：2012-09-06

  Methods and agents for reducing a level of an acetylated Tau polypeptide in a cell are provided. Methods for treating a tauopathy in an individual are also provided. Also provided is a method for diagnosing a cognitive impairment disorder in an individual. Methods for identifying an agent suitable for treating a tauopathy are also provided.
• Use of Sirt1 Activators or Inhibitors to Modulate an Immune Response
  申请人：THE J. DAVID GLADSTONE INSTITUTES

  公开号：US20140030295A1

  公开（公告）日：2014-01-30

  The present disclosure provides a method of increasing an immune response in an individual, the method involving administering to an individual in need thereof an inhibitor of SIRT1. The present disclosure provides a method of reducing an immune response, e.g., to treat chronic immune hyperactivity, the method generally involving administering to an individual in need thereof an activator of SIRT1. The present disclosure provides a method of modulating activation and differentiation of CD4 + T cells.