2-Hydroxy-2-(2-hydroxyphenyl)-1-phenylethanone | 74552-60-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-Hydroxy-2-(2-hydroxyphenyl)-1-phenylethanone
• CAS: 74552-60-6
• 化学式: C₁₄H₁₂O₃
• 分子量: 228.247
• InChiKey: KHXLVBLWUPHDMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  甲醇 、 2-Hydroxy-2-(2-hydroxyphenyl)-1-phenylethanone 在 盐酸 作用下， 以86%的产率得到3-Methoxy-2-phenylbenzofuran
  参考文献：
  名称：

  .alpha.-Heterosubstituted phosphonate carbanions. 11. Benzoins via an acyl anion equivalent. Novel one-pot preparation of benzo[b]furans via benzoins using hydriodic acid

  摘要：

  DOI：

  10.1021/jo01308a009
• 作为产物：
  描述：

  苯甲醛 在 sodium hydroxide 、 正丁基锂 、 水 、 二异丙胺 作用下， 反应 4.67h， 生成 2-Hydroxy-2-(2-hydroxyphenyl)-1-phenylethanone
  参考文献：
  名称：

  .alpha.-Heterosubstituted phosphonate carbanions. 11. Benzoins via an acyl anion equivalent. Novel one-pot preparation of benzo[b]furans via benzoins using hydriodic acid

  摘要：

  DOI：

  10.1021/jo01308a009

文献信息

• Derivatives of 4-methyl-5-(2-aminoethyl)-thiomethyl-imidazole having therapeutic activity
  申请人：Turconi, Franco

  公开号：EP0036684A1

  公开（公告）日：1981-09-30

  This invention relates to a series of compounds having therapeutic activity, consisting of the derivatives obtained by reacting 4-methyl-5-[(2-aminoethyl)-thiome- ' thyl]-imidazole with non-steroidal, traditional, antiinflammatory agents. The derivatives are carboxamides of formula wherein R1 = H; -CH3: -C2H5; and of the antiinflammatory agent, i.e. the acylic radical of the antiinflammatorv acid, or of the antiinflammatory acid and the corresponding physiologically acceptable salts on the imidazole ring.

  本发明涉及一系列具有治疗活性的化合物，由 4-甲基-5-[(2-氨基乙基)-thiome-'thyl]-咪唑与非类固醇、传统抗炎剂反应得到的衍生物组成。衍生物为式如下的羧酰胺类化合物 其中 R1 = H；-CH3：-C2H5；以及 消炎剂，即消炎酸的酰基，或 消炎酸和咪唑环上相应的生理上可接受的盐。
• Radiation curable resin and composition thereof
  申请人：Toyo Boseki Kabushiki Kaisha

  公开号：EP0394695A2

  公开（公告）日：1990-10-31

  A radiation curable resin which is a reaction product of: having at least two (meth)acryloyl groups at both terminal ends of a molecular chain which is obtained by reaction of (1) a polyester polyol and/or polycarbonate polyol, (2) a diisocyanate, (3) a polyfunctional (meth)acrylate containing a hydroxyl group therein, and optionally (4) a compound having at least two active hydrogens in the molecule is disclosed. The resin has at least two (meth)acryloyl groups at a terminal end of the molecular chain. The molecular weight of the resin is 1,000 to 50,000, the urethane bonding concentration is not more than 3,000 equivalent/10⁶ g and the (meth)acryloyl group concentration is 100 to 6,000 equivalent/10⁶ g. A radiation curable resin composition containing the resin and a precoated metal using the composition are also disclosed.

  本发明公开了一种辐射固化树脂，它是以下物质的反应产物：在分子链的两端至少有两个（甲基）丙烯酰基，该分子链是由（1）聚酯多元醇和/或聚碳酸酯多元醇、（2）二异氰酸酯、（3）含有羟基的多官能（甲基）丙烯酸酯和（4）分子中至少有两个活泼氢的化合物反应而得。该树脂的分子链末端至少有两个（甲基）丙烯酰基。还公开了含有该树脂的辐射固化树脂组合物和使用该组合物的预涂金属。
• Reductive coupling of benzoyl cyanide and carbonyl compounds by aqueous titanium(III) ions. A new convenient and selective access to the less stable mixed benzoins
  作者：Angelo Clerici、Ombretta Porta

  DOI：10.1021/jo00062a038

  日期：1993.5

  The reactive species formed by the Ti(III) ion reduction of benzoyl cyanide (1) adds to the C-atom of carbonyl compounds 2 under simple experimental conditions. The intermediate 1,2-diols 3 are smoothly converted, without isolation, into the less thermodynamically stable mixed benzoins 4, which are not accessible by the classical benzoin condensation. The possible mechanisms involved in the reaction are discussed.
• Asahina; Terasaka, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1923, # 494, p. 19
  作者：Asahina、Terasaka

  DOI：——

  日期：——
• KOENIGKRAMER R. E.; ZIMMER H., J. ORG. CEM., 1980, 45, NO 20, 3994-3998
  作者：KOENIGKRAMER R. E.、 ZIMMER H.

  DOI：——

  日期：——