3-(2,4-dimethylphenyl)-2-(2-chlorophenyl)-6-{2-[2-(2-chlorophenyl)-4-oxoquinazolin-3-yl]ethyl}quinazolin-4-one | 1309571-83-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(2,4-dimethylphenyl)-2-(2-chlorophenyl)-6-{2-[2-(2-chlorophenyl)-4-oxoquinazolin-3-yl]ethyl}quinazolin-4-one
• 英文别名: 2-(2-Chlorophenyl)-6-[2-[2-(2-chlorophenyl)-4-oxo-quinazolin-3-yl]ethyl]-3-(2,4-dimethylphenyl)quinazolin-4-one；2-(2-chlorophenyl)-6-[2-[2-(2-chlorophenyl)-4-oxoquinazolin-3-yl]ethyl]-3-(2,4-dimethylphenyl)quinazolin-4-one
• CAS: 1309571-83-2
• 化学式: C₃₈H₂₈Cl₂N₄O₂
• 分子量: 643.572
• InChiKey: JZUOTNIDGYPIFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  46
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  65.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(2-chlorophenyl)benzo[d]1,3-oxazin-4-one 在 吡啶 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 15.0h， 生成 3-(2,4-dimethylphenyl)-2-(2-chlorophenyl)-6-{2-[2-(2-chlorophenyl)-4-oxoquinazolin-3-yl]ethyl}quinazolin-4-one
  参考文献：
  名称：

  Dimeric 2-(2-chlorophenyl)-quinazolin-4-ones as potential antimicrobial agents

  摘要：

  3-(Aryl)-2-(2-chlorophenyl)-6-{2-[2-(2-chlorophenyl)-4-oxo(3-hydroquinazolin-3yl)]ethyl}-3-hydroquinazolin-4-ones had been selected as target bio-active molecules. Several quinazoline derivatives were prepared by using anthranilic acid, acid chloride, 2-amino-ethanol, and different amines. Newly synthesized compounds were screened for their antibacterial and antifungal activities on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogenes, Candida albicans, Aspergillus niger, and Aspergillus clavatus. The compounds 5e, 5g, and 5h are shown to have excellent activity, while 5c, 5d, 5i, 5k, 5l are shown to have very good activity against several strains of bacteria. The structures of the synthesized compounds were firmly established by well-defined spectral analysis techniques like IR, H-1-NMR, C-13-NMR, and Mass spectra.

  DOI：

  10.1007/s00044-011-9621-5

文献信息

• Dimeric 2-(2-chlorophenyl)-quinazolin-4-ones as potential antimicrobial agents
  作者：N. C. Desai、Amit Dodiya、Nayan Bhatt、Mukesh Kumar

  DOI：10.1007/s00044-011-9621-5

  日期：2012.7

  3-(Aryl)-2-(2-chlorophenyl)-6-2-[2-(2-chlorophenyl)-4-oxo(3-hydroquinazolin-3yl)]ethyl}-3-hydroquinazolin-4-ones had been selected as target bio-active molecules. Several quinazoline derivatives were prepared by using anthranilic acid, acid chloride, 2-amino-ethanol, and different amines. Newly synthesized compounds were screened for their antibacterial and antifungal activities on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogenes, Candida albicans, Aspergillus niger, and Aspergillus clavatus. The compounds 5e, 5g, and 5h are shown to have excellent activity, while 5c, 5d, 5i, 5k, 5l are shown to have very good activity against several strains of bacteria. The structures of the synthesized compounds were firmly established by well-defined spectral analysis techniques like IR, H-1-NMR, C-13-NMR, and Mass spectra.