1-(N-2-hydroxyethyl-N-methylaminomethyl)-2-naphthol | 123387-79-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(N-2-hydroxyethyl-N-methylaminomethyl)-2-naphthol
• 英文别名: 1-[[2-Hydroxyethyl(methyl)amino]methyl]naphthalen-2-ol
• CAS: 123387-79-1
• 化学式: C₁₄H₁₇NO₂
• 分子量: 231.294
• InChiKey: PGFBBBHYTSIJNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-甲基-1,3-噁唑啉 、 2-萘酚 以 乙腈 为溶剂， 反应 50.0h， 以95%的产率得到1-(N-2-hydroxyethyl-N-methylaminomethyl)-2-naphthol
  参考文献：
  名称：

  The functionalisation of electron rich aromatic compounds with 1,3-oxazolidines and 1,3-dimethylimidazolidine

  摘要：

  N-Phenyl- and N-alkyl-oxazolidines react with alkyl chlorosilanes in the presence of electron rich aromatic compounds with the formation of the expected Mannich bases: 2-methoxycarbonyl-3-methyloxazolidine also reacts with 2-methylfuran in the presence of thionyl chloride to give an a-amino acid derivative: the iminium salt derived from 1,3-dimethylimidazolidine was also shown to react with 2-methylfuran. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00922-8

文献信息

• Mannich reactions of oxazolidines
  作者：Robin A. Fairhurst、Harry Heaney、George Papageorgiou、Robert F. Wilkins、Stephen C. Eyley

  DOI：10.1016/s0040-4039(00)99485-1

  日期：1989.1
• FAIRHURST, ROBIN A.;HEANEY, HARRY;PAPAGEORGIOU, GEORGE;WILKINS, ROBERT F.+, TETRAHEDRON LETT., 30,(1989) N1, C. 1433-1436
  作者：FAIRHURST, ROBIN A.、HEANEY, HARRY、PAPAGEORGIOU, GEORGE、WILKINS, ROBERT F.+

  DOI：——

  日期：——
• The functionalisation of electron rich aromatic compounds with 1,3-oxazolidines and 1,3-dimethylimidazolidine
  作者：Harry Heaney、George Papageorgiou、Robert F. Wilkins

  DOI：10.1016/s0040-4020(97)00922-8

  日期：1997.10

  N-Phenyl- and N-alkyl-oxazolidines react with alkyl chlorosilanes in the presence of electron rich aromatic compounds with the formation of the expected Mannich bases: 2-methoxycarbonyl-3-methyloxazolidine also reacts with 2-methylfuran in the presence of thionyl chloride to give an a-amino acid derivative: the iminium salt derived from 1,3-dimethylimidazolidine was also shown to react with 2-methylfuran. (C) 1997 Elsevier Science Ltd.