7-bromo-1-oxido-1H-quinazolin-1-ium-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-bromo-1-oxido-1H-quinazolin-1-ium-2-one
• 化学式: C8H5BrN2O2
• 分子量: 241.04
• InChiKey: ZNLWPEYCPJCOSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Substituted Quinazoline and Pyrido-Pyrimidine Derivatives
  申请人：Endo Pharmaceuticals Inc.

  公开号：US20140073782A1

  公开（公告）日：2014-03-13

  The present application provides novel substituted quinazoline and pyrido-pyrimidine compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating PI3K and/or mTOR activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the PI3K/AKT/mTOR pathway. Advantageously, these compounds perform as dual PI3K/mTOR inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.

  本申请提供了新型取代的喹唑啉和吡啶并嘧啶化合物及其药学上可接受的盐。还提供了制备这些化合物的方法。通过向患者投予一种或多种化合物的治疗有效量，这些化合物在共同调节PI3K和/或mTOR活性方面具有用途。通过这样做，这些化合物对治疗与PI3K/AKT/mTOR通路失调相关的疾病有效。有利的是，这些化合物作为双重PI3K/mTOR抑制剂发挥作用。这些化合物可用于治疗多种病症，包括以炎症或异常细胞增殖为特征的疾病。在一种实施方案中，疾病是癌症。