(3R)-3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione;hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (3R)-3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione;hydrochloride
• 化学式: C14H15ClN4O3
• 分子量: 322.75
• InChiKey: BVJRNKXVSYLNFD-HNCPQSOCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.69
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] ISOTOPOLOGUES OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL) PIPERIDINE-2-6-DIONE AND METHODS OF PREPARATION THEREOF<br/>[FR] ISOTOPOLOGUES DE 3-(5-AMINO-2-MÉTHYL-4-OXOQUINAZOLIN-3(4H)-YL)PIPÉRIDINE-2,6-DIONE ET LEURS PROCÉDÉS DE PRÉPARATION
  申请人：CELGENE CORP

  公开号：WO2014039421A1

  公开（公告）日：2014-03-13

  Provided herein are deuterated isotopologues of 3-(5-amino-2-methyl-4- oxoquinazolin-3(4H)-yl)piperidine-2,6-dione, or enantiomers or mixtures of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, cocrystal or polymorph thereof, and processes for making the same. Pharmaceutical compositions comprising the isotopes- enriched compounds, and methods of using such compounds are also provided.

  本文提供了3-(5-氨基-2-甲基-4-氧喹唑啉-3(4H)-基)哌啶-2,6-二酮的氘同位素衍生物，或其对映体或对映体混合物；或其药学上可接受的盐、溶剂合物、共晶物或多型体，以及制备这些化合物的方法。还提供了含有同位素富集化合物的药物组合物，以及使用这些化合物的方法。
• ISOTOPOLOGUES OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL) PIPERIDINE-2-6-DIONE AND METHODS OF PREPARATION THEREOF
  申请人：Celgene Corporation

  公开号：US20150203469A1

  公开（公告）日：2015-07-23

  Provided herein are deuterated isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione, or enantiomers or mixtures of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, cocrystal or polymorph thereof, and processes for making the same. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are also provided.

  本文提供了3-(5-氨基-2-甲基-4-氧代喹唑啉-3(4H)-基)哌啶-2,6-二酮的氘同位素富集物，或其对映体或对映体混合物；或其药学上可接受的盐、溶剂合物、共晶体或多晶形，以及制备它们的过程。还提供了包含同位素富集化合物的制药组合物和使用这些化合物的方法。
• ISOTOPOLOGUES OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)PIPERIDINE-2,6-DIONE AND METHODS OF PREPARATION THEREOF
  申请人：Celgene Corporation

  公开号：US20180093965A1

  公开（公告）日：2018-04-05

  Provided herein are deuterated isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione, or enantiomers or mixtures of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, cocrystal or polymorph thereof, and processes for making the same. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are also provided.
• US9682952B2
  申请人：——

  公开号：US9682952B2

  公开（公告）日：2017-06-20