methylsulfinylmethane;N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

• 分子结构分类: 有机化合物 - 碳氢化合物衍生物 - 环庚三烯酮
• 英文名称: methylsulfinylmethane;N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
• 化学式: C24H31NO7S
• 分子量: 477.6
• InChiKey: MCJNUWWAMNADCC-NTISSMGPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.87
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  119
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] 5-AZAINDOLE COMPOUNDS WITH ANTICANCER AND ANTIANGIOGENIC ACTIVITIES<br/>[FR] COMPOSÉS 5-AZAINDOLE AYANT DES ACTIVITÉS ANTI-CANCER ET ANTI-ANGIOGÉNIQUE
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2014033597A1

  公开（公告）日：2014-03-06

  The present invention relates to 5-azaindole type compounds responding to the following formula (I): for their use as drugs, and more particularly for the prevention and/or the treatment of diseases and/or disorders chosen amongst cancers; angiogenesis related disorders; parasitic diseases; fungal diseases; autoimmune diseases; inflammatory diseases; warts such as warts caused by papilloma virus. The invention also relates to pharmaceutical compositions comprising such compounds of formula (I). The use of at least one compound of formula (I) as research tool for the cell-cycle synchronization of microtubule drugs resistant cell lines is also part of the invention. Finally, the invention also concerns the use of at least one compound of formula (I) as an herbicide and/or an algaecide.

  本发明涉及响应以下式（I）的5-氮杂吲哚类化合物的用途，用于药物，更具体地用于预防和/或治疗癌症等疾病和/或疾病，包括癌症；与血管生成相关的疾病；寄生虫病；真菌病；自身免疫性疾病；炎症性疾病；乳头状瘤病毒引起的疣等。该发明还涉及包含该式（I）化合物的药物组合物。至少一种式（I）化合物作为微管药物耐药细胞系细胞周期同步的研究工具的用途也是本发明的一部分。最后，该发明还涉及至少一种式（I）化合物作为除草剂和/或杀藻剂的用途。
• [EN] 5-AZAINDOLE COMPOUNDS WITH ANTICANCER AND ANTIANGIOGENIC ACTIVITIES<br/>[FR] COMPOSÉS DE 5-AZAINDOLE À ACTIVITÉ ANTI-CANCÉREUSE ET ANTI-ANGIOGÉNIQUE
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2014033497A1

  公开（公告）日：2014-03-06

  The present invention relates to 5-azaindole type compounds responding to the following formula (I): for their use as drugs, and more particularly for the prevention and/or the treatment of diseases and/or disorders chosen amongst cancers; angiogenesis related disorders; parasitic diseases; fungal diseases; autoimmune diseases; inflammatory diseases; warts such as warts caused by papilloma virus. The invention also relates to pharmaceutical compositions comprising such compounds of formula (I). The use of at least one compound of formula (I) as research tool for the cell-cycle synchronization of microtubule drugs resistant cell lines is also part of the invention. Finally, the invention also concerns the use of at least one compound of formula (I) as an herbicide and/or an algaecide.

  本发明涉及响应以下公式（I）的5-氮杂吲哚类化合物，用于作为药物，特别是用于预防和/或治疗癌症；血管生成相关疾病；寄生虫病；真菌病；自身免疫疾病；炎症性疾病；以及由乳头瘤病毒引起的疣等疾病和/或紊乱。本发明还涉及包含该公式（I）的化合物的制药组合物。使用至少一种公式（I）化合物作为细胞周期同步微管薯莨抗药性细胞系的研究工具也是本发明的一部分。最后，本发明还涉及使用至少一种公式（I）化合物作为除草剂和/或杀藻剂。