Ethyl 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methyl-3a,7a-dihydrobenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Ethyl 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methyl-3a,7a-dihydrobenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate
• 英文别名: ethyl 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methyl-3a,7a-dihydrobenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate
• 化学式: C₂₇H₃₁N₇O₃
• 分子量: 501.6
• InChiKey: QPQWCJCANYDIOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  37
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  137
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• PROCESS FOR THE PREPARATION OF CRYSTALLINE FORM I OF METHANESULFONATE SALT OF DABIGATRAN ETEXILATE
  申请人：RANBAXY LABORATORIES LIMITED

  公开号：US20150197504A1

  公开（公告）日：2015-07-16

  The present invention relates to a process for the preparation of crystalline Form I of methanesulfonate salt of dabigatran etexilate. (Formula (I)). The present invention does not require the isolation of the dabigatran etexilate intermediate.

  本发明涉及一种制备达比加群酯甲磺酸盐晶型I的方法。（化学式（I））。本发明不需要分离达比加群酯中间体。
• [EN] PROCESS FOR THE PREPARATION OF CRYSTALLINE FORM I OF METHANESULFONATE SALT OF DABIGATRAN ETEXILATE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE LA FORME CRISTALLINE I DU SEL MÉTHANESULFONATE D'ÉTÉXILATE DE DABIGATRAN
  申请人：RANBAXY LAB LTD

  公开号：WO2014033693A1

  公开（公告）日：2014-03-06

  The present invention relates to a process for the preparation of crystalline Form I of methanesulfonate salt of dabigatran etexilate. (Formula (I)). The present invention does not require the isolation of the dabigatran etexilate intermediate.

  本发明涉及一种制备达比加群酯甲磺酸盐晶型I的方法。(式(I))。本发明不需要分离达比加群酯中间体。
• PROCESS FOR THE PREPARATION OF DABIGATRAN ETEXILATE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
  申请人：RANBAXY LABORATORIES LIMITED

  公开号：US20150225370A1

  公开（公告）日：2015-08-13

  The present invention provides hydrobromide salt of dabigatran etexilate of formula (IV) and its process for the preparation. The present invention further provides crystalline Form I and crystalline Form II of hydrobromide salt of dabigatran etexilate and processes for their preparation. The present invention further relates to a process for the preparation of pharmaceutically ac ceptable salts, including methanesulfonate salt, of dabigatran etexilate using hydrobromide salt of dabigatran etexilate of the present invention.
• US9150542B2
  申请人：——

  公开号：US9150542B2

  公开（公告）日：2015-10-06