胺吸磷 | 78-53-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 胺吸磷
• 中文别名: S-[2-(二乙氨基)乙基]O，O-二乙基硫赶磷酸酯
• 英文名称: O,O-diethyl S-(2-diethylaminoethyl) thiophosphate
• 英文别名: amiton；thiophosphoric acid O,O'-diethyl ester-S-(2-diethylamino-ethyl ester)；Thiophosphorsaeure-O,O'-diaethylester-S-(2-diaethylamino-aethylester)；Monothiophosphorsaeure-O.O-diethyl-S-<2-diethylamino-ethyl>-ester；S-<2-Diethylamino-ethyl>-thiophosphorsaeure-O.O-diethylester；2-diethoxyphosphorylsulfanyl-N,N-diethylethanamine
• CAS: 78-53-5
• 化学式: C₁₀H₂₄NO₃PS
• 分子量: 269.345
• InChiKey: PJISLFCKHOHLLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  64.1
• 氢给体数：
  0
• 氢受体数：
  5

ADMET

毒理性

• 副作用

其他毒物 - 有机磷

Other Poison - Organophosphate

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

1. 确保气道通畅，如有必要，通过抽吸分泌物来清理。如果呼吸抑制，通过机械辅助肺通气给予氧气。在给予阿托品之前尽可能提高组织氧合，以最小化心室颤动的风险。在严重中毒的情况下，可能需要机械辅助肺通气数天。2. 给予硫酸阿托品静脉注射，如果静脉注射不可能，则肌内注射。在中度到重度中毒的情况下：成人剂量和12岁以上的儿童：每15分钟重复给予0.4-2.0毫克，直到达到阿托品化。维持阿托品化，根据体重每千克重复给予0.02-0.05毫克的剂量。/有机磷农药/

1. INSURE THAT A CLEAR AIRWAY EXISTS BY ASPIRATION OF SECRETIONS IF NECESSARY. ADMIN OXYGEN BY MECHANICALLY ASSISTED PULMONARY VENTILATION IF RESPIRATION IS DEPRESSED. IMPROVE TISSUE OXYGENATION AS MUCH AS POSSIBLE BEFORE ADMIN ATROPINE TO MINIMIZE RISK OF VENTRICULAR FIBRILLATION. IN SEVERE POISONINGS, IT MAY BE NECESSARY TO SUPPORT PULMONARY VENTILATION MECHANICALLY FOR SEVERAL DAYS. 2. ADMIN ATROPINE SULFATE IV, OR IM IF IV INJECTION IS NOT POSSIBLE. ... IN MODERATELY SEVERE POISONING: ADULT DOSAGE AND CHILDREN OVER 12 YR: 0.4-2.0 MG REPEATED EVERY 15 MIN UNTIL ATROPINIZATION IS ACHIEVED. MAINTAIN ATROPINIZATION WITH REPEATED DOSAGE OF 0.02-0.05 MG/KG BODY WEIGHT. /ORGANOPHOSPHATE PESTICIDES/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

2. 严重中毒的人可能对阿托品表现出显著的耐受性；可能需要使用上述建议剂量的两倍或更多。根据需要控制症状，可以增加阿托品的剂量并缩短给药间隔。当阿托品需求量巨大时，可能需要持续静脉输注阿托品。逆转毒蕈碱症状和体征是期望的终点，而不是任意剂量限制。尽可能使用不含防腐剂的阿托品产品。注意：未被有机磷农药中毒或仅轻微中毒的人可能会因使用如此大剂量的阿托品而出现阿托品中毒的迹象。发热、肌肉纤维颤动和谵妄是阿托品中毒的主要迹象。如果这些症状在患者完全阿托品化时出现，应暂时停止阿托品给药，同时重新评估中毒的严重程度。/有机磷农药/

2. SEVERELY POISONED INDIVIDUALS MAY EXHIBIT REMARKABLE TOLERANCE TO ATROPINE; TWO OR MORE TIMES THE DOSAGES SUGGESTED ABOVE MAY BE NEEDED. THE DOSE OF ATROPINE MAY BE INCREASED AND THE DOSING INTERVAL DECREASED AS NEEDED TO CONTROL SYMPTOMS. CONTINUOUS INTRAVENOUS INFUSION OF ATROPINE MAY BE NECESSARY WHEN ATROPINE REQUIREMENTS ARE MASSIVE. REVERSAL OF MUSCARINIC SYMPTOMS AND SIGNS, NOT AN ARBITRARY DOSE LIMIT, IS THE DESIRED END-POINT. PRESERVATIVE-FREE ATROPINE PRODUCTS SHOULD BE USED WHENEVER POSSIBLE. NOTE: PERSONS NOT POISONED OR ONLY SLIGHTLY POISONED BY ORGANOPHOSPHATES MAY DEVELOP SIGNS OF ATROPINE TOXICITY FROM SUCH LARGE DOSES. FEVER, MUSCLE FIBRILLATIONS, AND DELIRIUM ARE THE MAIN SIGNS OF ATROPINE TOXICITY. IF THESE APPEAR WHILE THE PATIENT IS FULLY ATROPINIZED, ATROPINE ADMINISTRATION SHOULD BE DISCONTINUED, AT LEAST TEMPORARILY, WHILE THE SEVERITY OF POISONING IS REEVALUATED. /ORGANOPHOSPHATE PESTICIDES/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

3. 在给予解磷定之前，抽取（肝素化）血液样本进行胆碱酯酶分析，因为解磷定往往会逆转胆碱酯酶的抑制。4. 在严重中毒的情况下给予解磷定（普罗帕米，2-PAM），在这些情况下呼吸抑制、肌肉无力和抽搐都非常严重。...成人剂量和12岁以上的儿童）：给予1.0-2.0克静脉注射，每分钟不超过0.2克。儿童剂量（12岁以下）：给予20-50毫克/千克（根据严重程度）静脉注射，每分钟注射的总量不超过一半。剂量...可以在1-2小时后重复，然后在需要时每10-12小时给药一次。在非常严重的中毒情况下，剂量...可以加倍。/有机磷农药/

3. DRAW BLOOD SAMPLE (HEPARINIZED) FOR CHOLINESTERASE ANALYSIS BEFORE ADMINISTRATION OF PRALIDOXIME, WHICH TENDS TO REVERSE THE CHOLINESTERASE DEPRESSION. 4. ADMIN PRALIDOXIME (PROTOPAM, 2-PAM) IN CASES OF SEVERE POISONING ... IN WHICH RESP DEPRESSION, MUSCLE WEAKNESS & TWITCHINGS ARE SEVERE. ... ADULT DOSAGE AND CHILDREN OVER 12): GIVE 1.0-2.0 G IV @ NO MORE THAN 0.2 G/MIN. CHILD'S DOSE (UNDER 12 YR): GIVE 20-50 MG/KG (DEPENDING ON SEVERITY) IV, INJECTING NO MORE THAN HALF TOTAL DOSE/MIN. DOSAGE ... MAY BE REPEATED IN 1-2 HR, THEN @ 10-12 HR INTERVAL IF NEEDED. IN VERY SEVERE POISONINGS, DOSAGE ... MAY BE DOUBLED. /ORGANOPHOSPHATE PESTICIDES/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

4. 准备好机械辅助呼吸，如果呼吸抑制...下降...。5. 对于因皮肤、衣物、头发和/或眼睛接触有机磷污染而中毒的患者，必须在进行复苏和解毒措施的同时进行去污处理，以保护生命。... 6. 如果...摄入的量足以引起中毒，必须清空胃和肠道。A. 通过插管、抽吸和灌洗清空胃，使用等渗盐水中的活性炭悬浮液。必须采取严格措施保护气道，防止反流的物质被吸入。如果受害者昏迷或反应迟钝，在进行胃插管之前插入带有气囊的气管内插管。在进行胃插管和灌洗时，保持受害者的头部低于胃部水平。...。保持受害者头部向左转。/有机磷杀虫剂/

4. BE PREPD TO ASSIST PULMONARY VENTILATION MECHANICALLY IF RESP ... DEPRESSED ... . 5. IN PATIENTS WHO HAVE BEEN POISONED BY ORGANOPHOSPHATE CONTAMINATION OF SKIN, CLOTHING, HAIR, AND/OR EYES, DECONTAMINATION MUST PROCEED CONCURRENTLY WITH WHATEVER RESUSCITATIVE AND ANTIDOTAL MEASURES ARE NECESSARY TO PRESERVE LIFE. ... 6. IF ... INGESTED IN QUANTITY PROBABLY SUFFICIENT TO CAUSE POISONING, THE STOMACH AND INTESTINE MUST BE EMPTIED. A. EMPTY THE STOMACH BY INTUBATION, ASPIRATION, AND LAVAGE, USING SLURRY OF ACTIVATED CHARCOAL IN ISOTONIC SALINE. RIGOROUS PRECAUTIONS MUST BE TAKEN TO PROTECT THE AIRWAY FROM ASPIRATION OF REGURGITATED. IF VICTIM IS UNCONSCIOUS OR OBTUNDED, INSERT A CUFFED ENDOTRACHEAL TUBE PRIOR TO GASTRIC INTUBATION. KEEP VICTIM'S HEAD BELOW LEVEL OF STOMACH DURING GASTRIC INTUBATION AND LAVAGE ... . KEEP VICTIM'S HEAD TURNED TO THE LEFT. /ORGANOPHOSPHATE PESTICIDES/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

有机磷农药通过消化道的粘膜、呼吸系统以及皮肤迅速被吸收进入人体，并由血液传送到各种身体组织。

Organophosphorus pesticides are rapidly absorbed into the body through the mucous membrane of the digestive tract, the respiratory system, & the skin, and are conveyed by the blood to various body tissues. /Organophosphorus pesticides/

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  胺吸磷 、 硫酸二甲酯 生成 O,O-Diethyl-S-(β-diethylaminoethyl)-thiophosphat-methyl-methosulfat
  参考文献：
  名称：

  Brestkin,A.P. et al., Doklady Chemistry, 1965, vol. 163, p. 655 - 657

  摘要：

  DOI：
• 作为产物：
  描述：

  bis(2-diethylaminoethyl)disulfide hydrochloride 在 磺酰氯 作用下， 以 二氯甲烷 为溶剂， 反应 1.33h， 生成 胺吸磷
  参考文献：
  名称：

  Petrov, K. A.; Rudnev, G. V.; Sorokin, V. D., Journal of general chemistry of the USSR, 1991, vol. 61, # 5.1, p. 1012 - 1014

  摘要：

  DOI：

文献信息

• [EN] MICROBIOCIDAL OXADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'OXADIAZOLE MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017157962A1

  公开（公告）日：2017-09-21

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.

  式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是杀菌剂有用。
• Thieno-pyrimidine compounds having fungicidal activity
  申请人：Brewster Kirkland William

  公开号：US20070093498A1

  公开（公告）日：2007-04-26

  The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.

  本发明涉及具有杀真菌活性的噻吩[2,3-d]-嘧啶化合物。
• [EN] INSECTICIDAL TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2013079350A1

  公开（公告）日：2013-06-06

  Compounds of the formula (I) or (I'), wherein the substituents are as defined in claim 1, are useful as pesticides.

  式(I)或(I')的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。
• Novel insecticides
  申请人：Syngenta Participations AG

  公开号：EP2540718A1

  公开（公告）日：2013-01-02

  Compounds of formula I wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as insecticides and can be prepared in a manner known per se.

  式I的化合物 其中取代基如权利要求1所定义，并且式I化合物的农药可接受盐以及所有立体异构体和互变异构形式可用作杀虫剂，并且可以按照已知的方法制备。
• Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
  申请人：Dow AgroSciences LLC

  公开号：US20180279612A1

  公开（公告）日：2018-10-04

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫具有杀虫效用的分子领域，用于生产此类分子的过程，用于此类过程的中间体，含有此类分子的杀虫组合物，以及使用此类杀虫组合物对抗此类害虫的过程。这些杀虫组合物可以用作螨虫剂、杀虫剂、螨虫剂、软体动物杀虫剂和线虫杀虫剂。本文件披露了具有以下式（“式一”）的分子。