N-(1-azabicyclo[2.2.2]octan-3-yl)-N-chloro-1-benzothiophene-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: N-(1-azabicyclo[2.2.2]octan-3-yl)-N-chloro-1-benzothiophene-2-carboxamide
• 化学式: C₁₆H₁₇ClN₂OS
• 分子量: 320.8
• InChiKey: NGVVFFNKVQJWBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• METHODS OF MAINTAINING, TREATING OR IMPROVING COGNITIVE FUNCTION
  申请人：Forum Pharmaceuticals Inc.

  公开号：EP2846796A1

  公开（公告）日：2015-03-18
• [EN] METHODS OF MAINTAINING, TREATING OR IMPROVING COGNITIVE FUNCTION<br/>[FR] PROCÉDÉS DE MAINTIEN, DE TRAITEMENT OU D'AMÉLIORATION DE LA FONCTION COGNITIVE
  申请人：ENVIVO PHARMACEUTICALS INC

  公开号：WO2013169646A1

  公开（公告）日：2013-11-14

  A method of administering an effective amount of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide, or a pharmaceutically acceptable salt thereof, to a patient in need thereof. One embodiment of the invention provides a method of maintaining, treating, curing and/or improving at least one cognitive function in a patient in need thereof, comprising: administering to the patient, for an extended period, an effective dose of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide, or a pharmaceutically acceptable salt thereof.