(E)-N-[4-(3-chloro-5-ethynylanilino)-7-(oxolan-3-yloxy)quinazolin-6-yl]-4-(diethylamino)but-2-enamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (E)-N-[4-(3-chloro-5-ethynylanilino)-7-(oxolan-3-yloxy)quinazolin-6-yl]-4-(diethylamino)but-2-enamide
• 化学式: C₂₈H₃₀ClN₅O₃
• 分子量: 520.0
• InChiKey: QZOOQDBXNMJXSK-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  37
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  88.6
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] SUBSTITUTED AMINOQUINAZOLINES USEFUL AS KINASES INHIBITORS<br/>[FR] AMINOQUINAZOLINES SUBSTITUÉES UTILES COMME INHIBITEURS DE KINASES
  申请人：TELIGENE LTD

  公开号：WO2013166952A1

  公开（公告）日：2013-11-14

  The present invention is directed to novel quinazolines, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The compounds and compositions of the present invention have protein kinases inhibitory activities and are expected to be useful for the treatment of protein kinases mediated diseases and conditions.

  本发明涉及新型喹唑啉类化合物及其衍生物、药用可接受的盐、溶剂合物和水合物。本发明的化合物和组合物具有蛋白激酶抑制活性，预计可用于治疗蛋白激酶介导的疾病和症状。
• SUBSTITUTED AMINOQUINAZOLINES USEFUL AS KINASES INHIBITORS
  申请人：TELIGENE LTD.

  公开号：US20150126539A1

  公开（公告）日：2015-05-07

  The present invention is directed to novel quinazolines, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The compounds and compositions of the present invention have protein kinases inhibitory activities and are expected to be useful for the treatment of protein kinases mediated diseases and conditions.

  本发明涉及新型喹唑啉、其衍生物、药学上可接受的盐、溶剂物和水合物。本发明的化合物和组合物具有蛋白激酶抑制活性，并有望用于治疗蛋白激酶介导的疾病和病状。
• US9388170B2
  申请人：——

  公开号：US9388170B2

  公开（公告）日：2016-07-12