3-(2-Hydroxyphenyl)propyl nitrate

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-(2-Hydroxyphenyl)propyl nitrate
• 英文别名: 3-(2-hydroxyphenyl)propyl nitrate
• 化学式: C9H11NO4
• 分子量: 197.19
• InChiKey: IWMSOKMGAKMZTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  75.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NITRIC OXIDE DONOR NEPRILYSIN INHIBITORS
  申请人：Theravance Biopharma R&D IP, LLC

  公开号：EP2855464A1

  公开（公告）日：2015-04-08
• [EN] NITRIC OXIDE DONOR NEPRILYSIN INHIBITORS<br/>[FR] INHIBITEURS DE NÉPRILYSINE DONNEURS D'OXYDE NITRIQUE
  申请人：THERAVANCE INC

  公开号：WO2013181332A1

  公开（公告）日：2013-12-05

  In one aspect, the invention relates to compounds having the formula: (I) where R1, R2, R3, R7, R8, Z, X, b, and c are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are nitric oxide donors and have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.